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Objectives <p>This study charted how investigations of tumour-microenvironment (TME) dynamics have shaped global thinking on drug resistance in breast cancer over the past three decades.</p> Methods <p>Web of Science Core Collection records (1995–2024) were harvested on 15 May 2025 with a three-block Boolean string integrating disease, microenvironmental, and resistance terms. After duplicate removal, document-type filtering, language restriction, and natural-language adjudication, 1 303 original articles and reviews remained. Bibliometrix (R 4.3.2) generated annual output, citation kinetics, and growth rates; VOSviewer (fractional counting, resolution = 1.0) mapped co-authorship, co-citation, and keyword networks.</p> Results <p>Publication volume expanded at a compound annual rate of 18.7%, progressing through formative (1995–2004), consolidation (2005–2012), and expansionary (2013–2024) epochs. Keyword drift traced a pivot from endocrine-centric lexicons (“tamoxifen”, “estrogen receptor”) to TME-immune discourse (“extracellular vesicles”, “tumour-associated macrophages”, “nanoparticles”); “microenvironment”, “hypoxia”, and “multidrug resistance” emerged as high-betweenness semantic bridges. The United States–China dyad accounted for 56.1% of output and anchored 24.4% of internationally co-authored papers, funnelling methodological innovation into an increasingly multipolar network, here defined as a collaboration graph containing at least four countries that each contribute ≥ 5% of total node-level betweenness centrality. Institutional overlays revealed late-decade ascendancy of East-Asian medical universities, while legacy North-American and European centres maintained brokerage dominance.</p> Conclusion <p>Bibliometric cartography documents a decisive ecological re-framing of breast-cancer drug-resistance research, with immune-stromal crosstalk supplanting receptor-centric models. Cross-border, multi-omics consortia that fuse East-Asian clinical scale with Western technological depth appear best poised to convert TME insights into resistance-reversing interventions.</p>

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Mapping thirty years of tumour-microenvironment-driven drug resistance in breast cancer: a global bibliometric analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月7日

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  • Zuoping Duan,
  • Yonghong Zhou,
  • Yang Wu

摘要

Objectives

This study charted how investigations of tumour-microenvironment (TME) dynamics have shaped global thinking on drug resistance in breast cancer over the past three decades.

Methods

Web of Science Core Collection records (1995–2024) were harvested on 15 May 2025 with a three-block Boolean string integrating disease, microenvironmental, and resistance terms. After duplicate removal, document-type filtering, language restriction, and natural-language adjudication, 1 303 original articles and reviews remained. Bibliometrix (R 4.3.2) generated annual output, citation kinetics, and growth rates; VOSviewer (fractional counting, resolution = 1.0) mapped co-authorship, co-citation, and keyword networks.

Results

Publication volume expanded at a compound annual rate of 18.7%, progressing through formative (1995–2004), consolidation (2005–2012), and expansionary (2013–2024) epochs. Keyword drift traced a pivot from endocrine-centric lexicons (“tamoxifen”, “estrogen receptor”) to TME-immune discourse (“extracellular vesicles”, “tumour-associated macrophages”, “nanoparticles”); “microenvironment”, “hypoxia”, and “multidrug resistance” emerged as high-betweenness semantic bridges. The United States–China dyad accounted for 56.1% of output and anchored 24.4% of internationally co-authored papers, funnelling methodological innovation into an increasingly multipolar network, here defined as a collaboration graph containing at least four countries that each contribute ≥ 5% of total node-level betweenness centrality. Institutional overlays revealed late-decade ascendancy of East-Asian medical universities, while legacy North-American and European centres maintained brokerage dominance.

Conclusion

Bibliometric cartography documents a decisive ecological re-framing of breast-cancer drug-resistance research, with immune-stromal crosstalk supplanting receptor-centric models. Cross-border, multi-omics consortia that fuse East-Asian clinical scale with Western technological depth appear best poised to convert TME insights into resistance-reversing interventions.