Objectives <p>This study aimed to (1) present a Spanish version of the Interpersonal Mindfulness Scale (IMS), while studying its psychometric properties, and (2) explore interpersonal mindfulness profiles, focusing on its similarities and differences when compared to previous evidence on intrapersonal mindfulness.</p> Method <p>Cross-sectional data on 683 Spanish nursing students were gathered. Together with the IMS, participants’ information on sociodemographic characteristics, intrapersonal mindfulness, positive and negative affect, dispositional hope, general self-efficacy, and resilient coping was gathered. Analyses included a sequence of confirmatory factor analyses and latent profile analysis (LPA), among others.</p> Results <p>Evidence pointed to a good fit for the four-factor with correlated factors solution, with adequate evidence of reliability. Four profiles were identified: (1) the <i>low mindfulness group</i>, with the most maladaptive psychosocial behavior; (2) the <i>reactingly present</i> group, with high levels in Presence and low in Nonreactivity, with a similar behavior to the intrapersonal <i>judgmentally observing</i> profile; (3) the <i>nonreactingly — not present</i>, with low levels of Presence and high in Nonreactivity, with a pattern of relationships close to the intrapersonal <i>non-judgmentally aware</i> profile; and (4) the <i>high mindfulness</i> profile, with the best psychosocial outcomes.</p> Conclusions <p>This study validates the IMS in Spanish and offers a reliable tool with which to measure interpersonal mindfulness. The four identified profiles present a number of similarities with those previously found in the intrapersonal mindfulness literature. We can talk of positive (<i>high mindfulness</i> and <i>nonreactingly — not present</i>) and negative (<i>low mindfulness</i> and <i>reactingly present</i>) profiles of interpersonal mindfulness.</p>