Objectives <p>This study aimed to (1) investigate the feasibility of three online-delivered mindfulness practices that emphasize different types of attentional focus: visceral body scan (VBS), somatosensory body scan (SBS), and external (non-body) meditation (ECM), and (2) gain insight into the potential effects of these interventions on interoceptive and other psychological outcomes.</p> Method <p>A pilot randomized controlled trial was conducted in a community-based sample recruited from social networks. It consisted of a 1-week online intervention of either VBS, SBS, or ECM. Feasibility measures included the study retention rate, adherence, mindfulness practice quality, mindfulness-related adverse effects, and acceptability. Several questionnaires on interoceptive, mindfulness, and emotional outcomes were administered before and after the intervention.</p> Results <p>A total of 48 adult individuals were enrolled. The retention rate was 66.20% and the adherence to the meditation practice was 56.53%. Acceptability and quality of the mindfulness practice were moderate, and most participants reported no adverse effects. We found some preliminary effects related to specific conditions (e.g., VBS was related to a decrease in attention to unpleasant bodily sensations), while other trends were found to be common among several conditions (e.g., VBS and SBS were associated with a preliminary decrease in the level of dampening of positive emotions).</p> Conclusions <p>Our findings suggest that improvements in feasibility are needed before this study design can be applied in larger-scale research. Hence, some refinements for the study protocol are proposed. Implications and future directions for this area of research are also discussed.</p> <p><b>Preregistration</b> This study was retrospectively registered in ClinicalTrials.gov on 31 January 2024 (NCT06237530).</p>