Objectives <p>Mindfulness-Based Art Interventions (MBAIs) have demonstrated potential in promoting psychosocial well-being in individuals. This review systematically investigated MBAIs in younger populations to explore participant demographics, intervention components, adaptations to participants’ characteristics, and mental health and well-being outcomes.</p> Methods <p>A systematic review was conducted across 18 electronic databases to identify both published and unpublished studies in English from January 2000 to August 2024 focusing on MBAIs for children and adolescents under 18. Twenty-six studies met the inclusion criteria and were selected for analysis.</p> Results <p>The reviewed studies illustrated the adaptability and positive impact of MBAIs for children and adolescents facing diverse psychosocial challenges across various socioeconomic statuses and settings, guided by facilitators with different trainings. The lack of a standardized MBAI protocol led to varied practices, structures, and durations among studies, complicating direct comparisons. Moreover, limited efforts were made to tailor interventions to participants’ characteristics. Despite this heterogeneity, core practices were identified across programs. Quantitative data predominantly showed significant reductions in internalizing symptoms and PTSD, along with improvements in attention. Qualitative findings also indicated improvements in psychosocial well-being among participants.</p> Conclusions <p>The review suggests that a variety of MBAI activities can be successfully designed and implemented, underscoring the program’s multidimensional nature, broad applicability, and potential impact across childhood and adolescence. Selecting, tailoring, and structuring the activities can be guided by the specific needs of the population by employing methods such as participatory approaches and co-design.</p>