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<p>Researchers have recently shown considerable interest in scientific studies related to nanotechnology, particularly in nanomedicine. Among the types of nanoparticles that have emerged in this field are those composed of two elements with a nanocomposite structure, especially those based on noble metals such as silver, which are easily coated with semiconducting nanoparticles such as zinc oxide. The techniques for manufacturing these nanoparticles vary depending on their intended applications. This research highlights the possibility of fabricating Ag-rich nanoparticles partially coated with zinc oxide using helium plasma jet technique. The resulting nanoparticles exhibited a positive surface charge of 5.2 mV. The research also investigates the changes in optical, electronic, and structural properties, surface morphology, sample size, and shape compared to those prepared using pulsed laser ablation. The novelty of this study lies in the fact that the similar cytotoxicity observed between our current study and previous ones, despite differences in shape and size (from 30 to 90 nanometers) as well as surface properties, may not be the primary determinants of the anticancer response in the current regimen. This may help in understanding the mechanism that controls the interaction of these nanostructures with the cell membrane of this type of cancer.</p>

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Synthesis and Characterization of Ag/ZnO Nanocomposites Prepared by Plasma Jet Technique as Potential Anti-Skin Cancer Agents

  • 期刊论文

  • 发表日期：

    2026年7月4日

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  • Sabah N. Mazhir,
  • Mohammed G. Hammed,
  • Ehsan M. Abbas,
  • Ali A. Khudhair

摘要

Researchers have recently shown considerable interest in scientific studies related to nanotechnology, particularly in nanomedicine. Among the types of nanoparticles that have emerged in this field are those composed of two elements with a nanocomposite structure, especially those based on noble metals such as silver, which are easily coated with semiconducting nanoparticles such as zinc oxide. The techniques for manufacturing these nanoparticles vary depending on their intended applications. This research highlights the possibility of fabricating Ag-rich nanoparticles partially coated with zinc oxide using helium plasma jet technique. The resulting nanoparticles exhibited a positive surface charge of 5.2 mV. The research also investigates the changes in optical, electronic, and structural properties, surface morphology, sample size, and shape compared to those prepared using pulsed laser ablation. The novelty of this study lies in the fact that the similar cytotoxicity observed between our current study and previous ones, despite differences in shape and size (from 30 to 90 nanometers) as well as surface properties, may not be the primary determinants of the anticancer response in the current regimen. This may help in understanding the mechanism that controls the interaction of these nanostructures with the cell membrane of this type of cancer.