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<p>Selenium nanoparticles (Se NPs) were synthesized and stabilized by different capping agents including chitosan (CS), bovine serum albumin (BSA), and polyvinyl alcohol (PVA). The three types of Se NPs (CS-Se NPs, BSA-Se NPs, and PVA-Se NPs) were characterized by using FT-IR, TEM, DLS, and zeta potential analysis. Their antibacterial activity was studied against a panel of multidrug-resistant pathogenic bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), <i>Klebsiella pneumoniae</i>, <i>Proteus mirabilis</i>, and <i>Burkholderia</i> spp, and sensitive antibiotic bacteria, including <i>Kocuria kristinae</i>, and <i>Streptococcus pneumoniae.</i> The obtained results indicated that the capping agent significantly influenced activity, with an efficacy order of CS-Se NPs &gt; BSA-Se NPs &gt; PVA-Se NPs. CS-Se NPs found to has the highest dose-dependent bactericidal activity, with lowest Minimum Inhibitory Concentration (MIC) (20–50&#xa0;µg/mL) and Minimum Bactericidal Concentration (MBC) (25–83&#xa0;µg/mL) values, related to BSA-Se NPs (41–100&#xa0;µg/mL for MIC, 50–200&#xa0;µg/mL for MBC), PVA-Se NPs (50–133&#xa0;µg/mL for MIC, 50–200&#xa0;µg/mL for MBC) and the standard antibiotic levofloxacin against some strains. Time-kill kinetics further revealed that the rapid and potent bactericidal action of CS-Se NPs. Comparing to BSA-SeNPs, and PVA-Se NPs, The bacterial density of tested were diminished by nearly 3 log after two hours of exposure to CS-SeNPs. These results clearly indicate that the choice of the capping agents used to stabilize Se NPs is a pivotal factor in modulating the antibacterial efficacy of Se NPs.</p>

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The Role of Stabilizing Agents in Enhancing the Antibacterial Activity of Selenium Nanoparticles Against Pathogenic Bacterial Strains

  • 期刊论文

  • 发表日期：

    2026年5月25日

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  • Dalal M. Ridha,
  • Ali H. Wdaah,
  • Afrah J. Abd Al-Zwaid,
  • Asim A. Balakit,
  • Hayder Abdul-Amir Maki Al-Hindy,
  • Mohammed J. Al-Awady

摘要

Selenium nanoparticles (Se NPs) were synthesized and stabilized by different capping agents including chitosan (CS), bovine serum albumin (BSA), and polyvinyl alcohol (PVA). The three types of Se NPs (CS-Se NPs, BSA-Se NPs, and PVA-Se NPs) were characterized by using FT-IR, TEM, DLS, and zeta potential analysis. Their antibacterial activity was studied against a panel of multidrug-resistant pathogenic bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, Proteus mirabilis, and Burkholderia spp, and sensitive antibiotic bacteria, including Kocuria kristinae, and Streptococcus pneumoniae. The obtained results indicated that the capping agent significantly influenced activity, with an efficacy order of CS-Se NPs > BSA-Se NPs > PVA-Se NPs. CS-Se NPs found to has the highest dose-dependent bactericidal activity, with lowest Minimum Inhibitory Concentration (MIC) (20–50 µg/mL) and Minimum Bactericidal Concentration (MBC) (25–83 µg/mL) values, related to BSA-Se NPs (41–100 µg/mL for MIC, 50–200 µg/mL for MBC), PVA-Se NPs (50–133 µg/mL for MIC, 50–200 µg/mL for MBC) and the standard antibiotic levofloxacin against some strains. Time-kill kinetics further revealed that the rapid and potent bactericidal action of CS-Se NPs. Comparing to BSA-SeNPs, and PVA-Se NPs, The bacterial density of tested were diminished by nearly 3 log after two hours of exposure to CS-SeNPs. These results clearly indicate that the choice of the capping agents used to stabilize Se NPs is a pivotal factor in modulating the antibacterial efficacy of Se NPs.