Scholarlink

<p>The nanocomposite (Bioactive glass (BG)-gold nanoparticles (AuNPs)-chitosan) nanocomposite was synthesized using simple and effective sol-gel and wet chemical techniques. High-resolution transmission electron microscopy (HRTEM) results exhibited the particle size of 10.7 and 12.3&#xa0;nm for BG-AuNPs and BG-AuNPs-chitosan nanocomposites, respectively. The interaction between BG, AuNPs, and chitosan was discussed using various physicochemical techniques. The X-ray diffraction (XRD) pattern resembles calcium phosphate silicate structures with inherent planes of AuNPs and amorphous chitosan. X-ray photoelectron spectroscopy (XPS) implies a reasonable electrostatic interaction between the BG, AuNPs, and chitosan with a shift in their specific/native states (83.54, 103.36, 347.36, 133.51&#xa0;eV for Au4f<sub>7/2</sub>, Si<sup>4+</sup>, Ca2p<sub>3/2</sub>, P2p<sub>3/2</sub>). Brunauer-Emmett-Teller (BET) analysis reveals the BG-AuNPs and BG-AuNPs-chitosan’s nanocomposite surface area as 13.048 and 45.35 m<sup>2</sup>/g, pore diameter as 5.9 and 1.2&#xa0;nm with mesoporous type IV isotherm, respectively. Anti-oxidant (68%), cell viability (89%), and cell proliferation (higher cell multiplication; at 100 µL) results significantly influence the bioimaging capability towards L929 fibroblast cells. Eventually, BG-AuNPs-chitosan nanocomposite was involved in the drug delivery system using metronidazole (MT) drug and achieved a greater interaction, sustainable loading, and controlled release over time for extended hours with zero-order kinetics formation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Ternary Nanocomposite comprised of Gold, Bioglass, and Biopolymer for Drug Delivery and Bioimaging Applications

  • 期刊论文

  • 发表日期：

    2026年5月26日

查看全文
  • Manjubaashini Nandhakumar,
  • Elakkiya Krishnamoorthy,
  • Shalini Thomas,
  • Balakumar Subramanian

摘要

The nanocomposite (Bioactive glass (BG)-gold nanoparticles (AuNPs)-chitosan) nanocomposite was synthesized using simple and effective sol-gel and wet chemical techniques. High-resolution transmission electron microscopy (HRTEM) results exhibited the particle size of 10.7 and 12.3 nm for BG-AuNPs and BG-AuNPs-chitosan nanocomposites, respectively. The interaction between BG, AuNPs, and chitosan was discussed using various physicochemical techniques. The X-ray diffraction (XRD) pattern resembles calcium phosphate silicate structures with inherent planes of AuNPs and amorphous chitosan. X-ray photoelectron spectroscopy (XPS) implies a reasonable electrostatic interaction between the BG, AuNPs, and chitosan with a shift in their specific/native states (83.54, 103.36, 347.36, 133.51 eV for Au4f7/2, Si4+, Ca2p3/2, P2p3/2). Brunauer-Emmett-Teller (BET) analysis reveals the BG-AuNPs and BG-AuNPs-chitosan’s nanocomposite surface area as 13.048 and 45.35 m2/g, pore diameter as 5.9 and 1.2 nm with mesoporous type IV isotherm, respectively. Anti-oxidant (68%), cell viability (89%), and cell proliferation (higher cell multiplication; at 100 µL) results significantly influence the bioimaging capability towards L929 fibroblast cells. Eventually, BG-AuNPs-chitosan nanocomposite was involved in the drug delivery system using metronidazole (MT) drug and achieved a greater interaction, sustainable loading, and controlled release over time for extended hours with zero-order kinetics formation.