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<p>Gold nanorods (AuNRs) were synthesized via a seedless method and subsequently encapsulated within the curcumin encapsulated bovine serum albumin (Cur@BSA) to form (AuNRs&amp;Cur)@BSA. The lengths of the synthesized AuNRs are found to be 13 ± 2&#xa0;nm and the width 4 ± 1&#xa0;nm. Given an aspect ratio of approximately 3, the AuNRs were expected and established to be NIR-active; thus, a water-suspended (AuNRs&amp;Cur)@BSA hybrid nanofluid was prepared for use as an NIR-active injectable nanomedicine. As a control for unwanted cell growth, curcumin was also encapsulated with AuNRs. The nanofluid and its ingredients were studied using dynamic light scattering (DLS), UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscopy (TEM), and Fluorescence spectroscopy. The synthesized hybrid nanofluid exhibited an encapsulation efficiency of 90% and a drug loading capacity of 12%, indicating its suitability for nanomedicine applications. </p> Graphical Abstract <p></p>

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Fabrication and Characterization of a NIR-Responsive Hybrid Nanofluid: BSA-Encapsulated Gold Nanorods Loaded with Curcumin for a Potential Drug Delivery

  • 期刊论文

  • 发表日期：

    2026年5月7日

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  • U. Priyadharshini,
  • Jayanta Parui

摘要

Gold nanorods (AuNRs) were synthesized via a seedless method and subsequently encapsulated within the curcumin encapsulated bovine serum albumin (Cur@BSA) to form (AuNRs&Cur)@BSA. The lengths of the synthesized AuNRs are found to be 13 ± 2 nm and the width 4 ± 1 nm. Given an aspect ratio of approximately 3, the AuNRs were expected and established to be NIR-active; thus, a water-suspended (AuNRs&Cur)@BSA hybrid nanofluid was prepared for use as an NIR-active injectable nanomedicine. As a control for unwanted cell growth, curcumin was also encapsulated with AuNRs. The nanofluid and its ingredients were studied using dynamic light scattering (DLS), UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscopy (TEM), and Fluorescence spectroscopy. The synthesized hybrid nanofluid exhibited an encapsulation efficiency of 90% and a drug loading capacity of 12%, indicating its suitability for nanomedicine applications.

Graphical Abstract