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<p>The study reports the synthesis, characterization and evaluation of antimicrobial performance of moxifloxacin -loaded chitosan nanoparticles as a strategy to improve moxifloxacin stability, solubility and controlled release against pathogenic bacteria. Chitosan nanoparticles were prepared via the ionic gelation method using sodium tripolyphosphate as cross linker with varying moxifloxacin-chitosan ratios. The formulations were characterized for particle size, polydispersity index, percentage yield, FTIR, SEM, TGA and XRD. Antibacterial activity was assessed against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> using the disc diffusion method. Results showed particle sizes ranging from 285.9 to 365.1 nm, increasing with chitosan content, while the optimal formulation (450 mg Mox/100 mg CN) exhibited the highest yield of 17.33%. FTIR confirmed successful drug encapsulation without chemical degradation, while SEM revealed a transition from crystalline moxifloxacin particles to porous, amorphous chitosan matrices. XRD revealed progressive amorphization of moxifloxacin within the chitosan matrix, correlating with improved solubility potential and TGA indicated enhanced thermal stability of the nanoformulations. Although encapsulation slightly reduced immediate antibacterial zones, sustained antimicrobial activity was observed, consistent with controlled drug release. The research correlates chitosan content-dependent physicochemical transformations with antimicrobial performance which emphasized moxifloxacin-chitosan nanoparticles (Mox-CNPs) as a promising controlled-release antibiotic delivery system.</p>

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Synthesis, Characterization and Antimicrobial Assessment of Moxifloxacin-Loaded Chitosan Nanoparticles

  • 期刊论文

  • 发表日期：

    2026年3月21日

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  • Levi Dooga,
  • Casimir Emmanuel Gimba,
  • Hamza Abba,
  • Muhammad Tukur Ibrahim,
  • Yonni Eshovo Apeji

摘要

The study reports the synthesis, characterization and evaluation of antimicrobial performance of moxifloxacin -loaded chitosan nanoparticles as a strategy to improve moxifloxacin stability, solubility and controlled release against pathogenic bacteria. Chitosan nanoparticles were prepared via the ionic gelation method using sodium tripolyphosphate as cross linker with varying moxifloxacin-chitosan ratios. The formulations were characterized for particle size, polydispersity index, percentage yield, FTIR, SEM, TGA and XRD. Antibacterial activity was assessed against Escherichia coli and Staphylococcus aureus using the disc diffusion method. Results showed particle sizes ranging from 285.9 to 365.1 nm, increasing with chitosan content, while the optimal formulation (450 mg Mox/100 mg CN) exhibited the highest yield of 17.33%. FTIR confirmed successful drug encapsulation without chemical degradation, while SEM revealed a transition from crystalline moxifloxacin particles to porous, amorphous chitosan matrices. XRD revealed progressive amorphization of moxifloxacin within the chitosan matrix, correlating with improved solubility potential and TGA indicated enhanced thermal stability of the nanoformulations. Although encapsulation slightly reduced immediate antibacterial zones, sustained antimicrobial activity was observed, consistent with controlled drug release. The research correlates chitosan content-dependent physicochemical transformations with antimicrobial performance which emphasized moxifloxacin-chitosan nanoparticles (Mox-CNPs) as a promising controlled-release antibiotic delivery system.