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<p>Iron nanoparticles (Fe NPs) have gained attention in biomedical applications owing to their strong antimicrobial properties, including antibacterial and antifungal effects. This study investigated the development of a novel denture adhesive gel incorporating Fe NPs, Aloe vera, and chitosan, designed to enhance both adhesive strength and microbial inhibition, addressing the limitations of traditional denture adhesives.&#xa0;To develop an iron nanoparticle-based denture adhesive gel with enhanced antibacterial and antifungal properties and to evaluate its adhesive bond strength and antimicrobial efficacy compared to a commercially available denture adhesive.&#xa0;Study Setting and Design: Research exploring an iron nanoparticle-based denture adhesive gel took place in vitro to determine its adhesive properties, alongside antimicrobial effectiveness, pH stability and cytotoxicity compared to available market gel products. Materials and Methods: A novel denture adhesive gel was formulated using Fe NPs, Aloe vera gel, and chitosan. The adhesive bond strength was measured in vitro under dry and wet conditions using a universal testing machine over a 20-minute interval. The antimicrobial activity was tested against <i>Streptococcus mutans</i>,<i> Staphylococcus aureus</i>,<i> and Candida albicans</i>. The pH stability and cytotoxicity of the novel and commercial adhesives were evaluated in this study. Statistical Analysis Used: Statistical analysis was performed using descriptive statistics (mean ± SD). Research groups were evaluated for adhesive strength and antimicrobial efficacy using Student’s t-test and one-way ANOVA. Statistical significance was set at <i>p</i> &lt; 0.05. Results: Experimental adhesive bonds made with Fe NPs have strengths similar to those of commercially available products. The antibacterial and antifungal properties of this product have proven effective against <i>Streptococcus mutans and Candida albicans</i>. The novel formulation exhibited a lower pH (5.78) than the commercial products (6.27) because it did not contain harmful ingredients such as zinc and formaldehyde. Conclusion: The scalability of Fe NP-based denture adhesive gels remains limited owing to pH optimization requirements, although they show potential as antimicrobial agents with proper adhesive strength to prevent infections.</p>

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Development of an Iron Nanoparticle-Based Antibacterial and Antifungal Denture Adhesive Gel: an In Vitro Evaluation of Adhesive Strength and Microbial Inhibition

  • 期刊论文

  • 发表日期：

    2026年3月5日

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  • Santosh Y. Nelogi,
  • Pallavi Luthra

摘要

Iron nanoparticles (Fe NPs) have gained attention in biomedical applications owing to their strong antimicrobial properties, including antibacterial and antifungal effects. This study investigated the development of a novel denture adhesive gel incorporating Fe NPs, Aloe vera, and chitosan, designed to enhance both adhesive strength and microbial inhibition, addressing the limitations of traditional denture adhesives. To develop an iron nanoparticle-based denture adhesive gel with enhanced antibacterial and antifungal properties and to evaluate its adhesive bond strength and antimicrobial efficacy compared to a commercially available denture adhesive. Study Setting and Design: Research exploring an iron nanoparticle-based denture adhesive gel took place in vitro to determine its adhesive properties, alongside antimicrobial effectiveness, pH stability and cytotoxicity compared to available market gel products. Materials and Methods: A novel denture adhesive gel was formulated using Fe NPs, Aloe vera gel, and chitosan. The adhesive bond strength was measured in vitro under dry and wet conditions using a universal testing machine over a 20-minute interval. The antimicrobial activity was tested against Streptococcus mutans, Staphylococcus aureus, and Candida albicans. The pH stability and cytotoxicity of the novel and commercial adhesives were evaluated in this study. Statistical Analysis Used: Statistical analysis was performed using descriptive statistics (mean ± SD). Research groups were evaluated for adhesive strength and antimicrobial efficacy using Student’s t-test and one-way ANOVA. Statistical significance was set at p < 0.05. Results: Experimental adhesive bonds made with Fe NPs have strengths similar to those of commercially available products. The antibacterial and antifungal properties of this product have proven effective against Streptococcus mutans and Candida albicans. The novel formulation exhibited a lower pH (5.78) than the commercial products (6.27) because it did not contain harmful ingredients such as zinc and formaldehyde. Conclusion: The scalability of Fe NP-based denture adhesive gels remains limited owing to pH optimization requirements, although they show potential as antimicrobial agents with proper adhesive strength to prevent infections.