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<p>The rapid, reliable, and accurate detection of the stress hormone cortisol is pivotal for achieving early-stage diagnosis for evaluating dysregulation-adrenal functions and chronic stress related disorders/syndromes. Recently, zinc oxide (ZnO) tetrapods have provided unique opportunities in sensing as a result of their tailored defect chemistry, high surface reactivity and morphological resilience. Here, a cost-effective and efficient in-situ gold (Au) nanoparticles decorated 3D ZnO tetrapods (Au@ZnO) was fabricated and characterized by various physicochemical and analytical techniques. Transmission electron microscopic images exhibited the nearly uniform decoration of Au nanoparticles (with a mean diameter of &lt; 10&#xa0;nm) on the micron size 3D ZnO tetrapods. The fabricated Au@ZnO electrode was used for deploying selective and sensitive electrochemical detection of cortisol in human sweat. The cyclic voltammetry revealed the redox-active behaviour of Au@ZnO and corresponding peaks indicates the successful surface modification with Au nanoparticles. Further, the Au@ZnO sensor demonstrated a strong binding affinity with the antibody for cortisol binding (81.1%) and also exhibited a linear concentration range of1 fg/mL to 100ng/mL and a detection limit of 0.24&#xa0;fg/mL. The sensor was effectively demonstrated to measure cortisol levels in spiked sweat with excellent recovery as 73.56–97.76%.</p>

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Gold-Decorated 3D ZnO Tetrapods Enabling Enhanced Electrochemical Sensing of Cortisol

  • 期刊论文

  • 发表日期：

    2026年2月21日

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  • Shruti Shukla,
  • Mercyland Pamshong,
  • Ibansaralang Kharthangmaw,
  • Shivalingayya Gaddimath,
  • Hira Abdullah,
  • Azmat Ali Khan,
  • Amer M. Alanazi,
  • Yogendra Kumar Mishra,
  • Yuvaraj Haldorai

摘要

The rapid, reliable, and accurate detection of the stress hormone cortisol is pivotal for achieving early-stage diagnosis for evaluating dysregulation-adrenal functions and chronic stress related disorders/syndromes. Recently, zinc oxide (ZnO) tetrapods have provided unique opportunities in sensing as a result of their tailored defect chemistry, high surface reactivity and morphological resilience. Here, a cost-effective and efficient in-situ gold (Au) nanoparticles decorated 3D ZnO tetrapods (Au@ZnO) was fabricated and characterized by various physicochemical and analytical techniques. Transmission electron microscopic images exhibited the nearly uniform decoration of Au nanoparticles (with a mean diameter of < 10 nm) on the micron size 3D ZnO tetrapods. The fabricated Au@ZnO electrode was used for deploying selective and sensitive electrochemical detection of cortisol in human sweat. The cyclic voltammetry revealed the redox-active behaviour of Au@ZnO and corresponding peaks indicates the successful surface modification with Au nanoparticles. Further, the Au@ZnO sensor demonstrated a strong binding affinity with the antibody for cortisol binding (81.1%) and also exhibited a linear concentration range of1 fg/mL to 100ng/mL and a detection limit of 0.24 fg/mL. The sensor was effectively demonstrated to measure cortisol levels in spiked sweat with excellent recovery as 73.56–97.76%.