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<p>Electrospun nanofiber scaffolds offer extracellular matrix (ECM) like architecture and tunable physicochemical properties that make them highly suitable for regenerative wound care. In this work, a multifunctional hyaluronic acid–glutathione–polyvinyl alcohol (HA–GSH–PVA) nanofiber scaffold was fabricated to integrate structural support with localized redox modulation. FTIR confirmed successful incorporation of HA and GSH within the hydrogen-bonded PVA matrix, while DSC analysis revealed reduced crystallinity and enhanced thermal stability. UV–DRS measurements reflected a wide-band-gap, optically stable composite. SEM and TEM imaging demonstrated uniform, bead-free fibers (100 nm) with dense internal morphology. The scaffold exhibited a tensile strength of 3.7 ± 0.3 MPa, elongation of 48 ± 5%, and a modulus of 85 ± 8 MPa, consistent with the mechanical range required for flexible wound dressings. In vitro assays showed excellent cytocompatibility, maintaining &gt;85% fibroblast viability at functional concentrations. Scratch assays demonstrated concentration-dependent enhancement in fibroblast migration, achieving 88% wound closure at 32 µg/mL within 24 h. These results establish the HA–GSH–PVA scaffold as a redox-active, ECM mimetic nanofibrous platform with strong potential for next-generation antioxidant-enriched wound-healing applications.</p> Graphical Abstract <p></p>

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Electrospun HA–GSH–PVA Nanofiber Scaffolds for Enhanced Fibroblast Migration and Accelerated Wound Healing

  • 期刊论文

  • 发表日期：

    2026年3月17日

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  • Ranjani Muthu,
  • Renukadevi Jeyavelkumaran,
  • Magesh Mohan

摘要

Electrospun nanofiber scaffolds offer extracellular matrix (ECM) like architecture and tunable physicochemical properties that make them highly suitable for regenerative wound care. In this work, a multifunctional hyaluronic acid–glutathione–polyvinyl alcohol (HA–GSH–PVA) nanofiber scaffold was fabricated to integrate structural support with localized redox modulation. FTIR confirmed successful incorporation of HA and GSH within the hydrogen-bonded PVA matrix, while DSC analysis revealed reduced crystallinity and enhanced thermal stability. UV–DRS measurements reflected a wide-band-gap, optically stable composite. SEM and TEM imaging demonstrated uniform, bead-free fibers (100 nm) with dense internal morphology. The scaffold exhibited a tensile strength of 3.7 ± 0.3 MPa, elongation of 48 ± 5%, and a modulus of 85 ± 8 MPa, consistent with the mechanical range required for flexible wound dressings. In vitro assays showed excellent cytocompatibility, maintaining >85% fibroblast viability at functional concentrations. Scratch assays demonstrated concentration-dependent enhancement in fibroblast migration, achieving 88% wound closure at 32 µg/mL within 24 h. These results establish the HA–GSH–PVA scaffold as a redox-active, ECM mimetic nanofibrous platform with strong potential for next-generation antioxidant-enriched wound-healing applications.

Graphical Abstract