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<p>This study presents the biological synthesis of Ag@Ag<sub>2</sub>O core-shell nanoparticles using the probiotic strain <i>Pediococcus pentosaceus</i> TP11, offering an eco-friendly strategy to combat the escalating threat of antimicrobial resistance (AMR). Metabolomic profiling of the strain identified bioactive compounds including phenolics, terpenoids, organic acids and polysaccharides which were instrumental in the biosynthesis and stabilization of Ag@Ag<sub>2</sub>O NPs. The nanoparticles were thoroughly characterized: UV–Visible spectroscopy confirmed their formation, DLS revealed an average hydrodynamic size of 144&#xa0;nm and XRD indicated a crystalline size of 19&#xa0;nm. Elemental analysis through XPS and EDS with XRD confirmed the core shell structure of Ag@Ag<sub>2</sub>O nanoparticle, morphological assessment via FE-SEM and functional group identification by FTIR further validated their structure and composition. Functionally, the Ag@Ag<sub>2</sub>O NPs exhibited potent antibacterial and antibiofilm activity against pathogenic bacteria primarily mediated through oxidative stress induction and disruption of bacterial membranes mechanisms less prone to inducing resistance. Importantly hemolysis assays using goat red blood cells showed dose dependent minimal cytotoxicity, highlighting their biocompatibility. These results demonstrate the promise of <i>P. pentosaceus</i> TP11 derived Ag@Ag<sub>2</sub>O core-shell NPs as a next-generation antimicrobial agent to counteract AMR, potentially reducing dependence on traditional antibiotics.</p>

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Bio Fabrication of Ag@Ag2O Core -Shell Nanoparticles Using Pediococcus Pentosaceus TP11: Structural Characterization and Antimicrobial Potential

  • 期刊论文

  • 发表日期：

    2026年2月16日

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  • Tamanna Parvin,
  • Sudha Rani Sadras,
  • Deepika Pagalavan

摘要

This study presents the biological synthesis of Ag@Ag2O core-shell nanoparticles using the probiotic strain Pediococcus pentosaceus TP11, offering an eco-friendly strategy to combat the escalating threat of antimicrobial resistance (AMR). Metabolomic profiling of the strain identified bioactive compounds including phenolics, terpenoids, organic acids and polysaccharides which were instrumental in the biosynthesis and stabilization of Ag@Ag2O NPs. The nanoparticles were thoroughly characterized: UV–Visible spectroscopy confirmed their formation, DLS revealed an average hydrodynamic size of 144 nm and XRD indicated a crystalline size of 19 nm. Elemental analysis through XPS and EDS with XRD confirmed the core shell structure of Ag@Ag2O nanoparticle, morphological assessment via FE-SEM and functional group identification by FTIR further validated their structure and composition. Functionally, the Ag@Ag2O NPs exhibited potent antibacterial and antibiofilm activity against pathogenic bacteria primarily mediated through oxidative stress induction and disruption of bacterial membranes mechanisms less prone to inducing resistance. Importantly hemolysis assays using goat red blood cells showed dose dependent minimal cytotoxicity, highlighting their biocompatibility. These results demonstrate the promise of P. pentosaceus TP11 derived Ag@Ag2O core-shell NPs as a next-generation antimicrobial agent to counteract AMR, potentially reducing dependence on traditional antibiotics.