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<p>An artificial skin with a porous structure, made from gelatin, cross-linked using glutaraldehyde (GA), and integrated with zinc oxide nanoparticles, was developed using scaffold technology. Zinc oxide nanoparticles were synthesized and added to the artificial skin samples at varied concentrations (0.5-3&#xa0;mg). Results showed that increasing zinc oxide content reduced water absorption by enhanced crosslinking and pore filling, while slightly delaying degradation to 22 days and increasing antimicrobial activity, especially against Gram-positive strains. Fourier transform infrared spectroscopy (FT-IR) analysis confirmed interactions between zinc oxide and gelatin matrix. Scanning electron microscopy (SEM) confirmed porous morphology with well-dispersed nanoparticles. The optimized sample with 3&#xa0;mg zinc oxide nanoparticles demonstrated sustained nanoparticle release over 22 days following first-order kinetics model more strongly with regression coefficient of 0.912, strong antimicrobial activity, fast wound healing and hair re-growth, reduced scarring, enhanced bio-adhesion, and a suitable thickness of 0.52&#xa0;mm, confirming its suitability to work as an excellent skin substitute, and these features increased the novelty of this work. These findings confirmed that zinc oxide nanoparticle-containing artificial skin scaffolds had strong potential for skin regeneration.</p>

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Development and Investigation of Artificial Skin with Zinc Oxide Nanoparticles for Skin Regeneration

  • 期刊论文

  • 发表日期：

    2026年2月16日

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  • Alishba Azhar,
  • Zeeshan Danish,
  • Hamid Saeed

摘要

An artificial skin with a porous structure, made from gelatin, cross-linked using glutaraldehyde (GA), and integrated with zinc oxide nanoparticles, was developed using scaffold technology. Zinc oxide nanoparticles were synthesized and added to the artificial skin samples at varied concentrations (0.5-3 mg). Results showed that increasing zinc oxide content reduced water absorption by enhanced crosslinking and pore filling, while slightly delaying degradation to 22 days and increasing antimicrobial activity, especially against Gram-positive strains. Fourier transform infrared spectroscopy (FT-IR) analysis confirmed interactions between zinc oxide and gelatin matrix. Scanning electron microscopy (SEM) confirmed porous morphology with well-dispersed nanoparticles. The optimized sample with 3 mg zinc oxide nanoparticles demonstrated sustained nanoparticle release over 22 days following first-order kinetics model more strongly with regression coefficient of 0.912, strong antimicrobial activity, fast wound healing and hair re-growth, reduced scarring, enhanced bio-adhesion, and a suitable thickness of 0.52 mm, confirming its suitability to work as an excellent skin substitute, and these features increased the novelty of this work. These findings confirmed that zinc oxide nanoparticle-containing artificial skin scaffolds had strong potential for skin regeneration.