<p>Imazethapyr is a widely used herbicide in soybean cultivation, known for its low soil adsorption coefficient (Koc), which often leads to leaching and reduced field persistence. To address these challenges and improve bioefficacy while reducing application costs, sustained-release formulations have gained significant interest in smart agriculture practices. Sustain release of herbicide is critical and an important aspect in smart agriculture practices. It is directly impact on bio efficacy which helps to save the cost of herbicide as recommended doses are lesser than conventional formulation. The release kinetics of chitosanclay imazethapyr nanocomposites (CCINC) were studied under different pH conditions to understand their release behavior. In continuation of our previous work, CCINC based on bentonite clay and chitosan with a 75% degree of deacetylation (DDA) were successfully prepared at three different concentrations of Imazethapyr viz. 24.14%, 44.16% and 61.2% (w/w). The release behavior of these nanocomposites was examined under different pH conditions to assess the influence of imazethapyr concentration on release kinetics. The release kinetics of CCINC have been investigated in environments such as buffers of pH 2, pH 4, and pH 6. High-Performance Liquid Chromatography (HPLC) was used to quantify imazethapyr in the buffer solution after its release from the nanocomposites. Higuchi model support the release of through diffusion mechanism and Imazethapyr release rate fit in this model. Correlation coefficient (R2 R²) has been calculated based on the graph plotted as Cumulative % drug released Vs Square root time graph. Kinetic model like Higuchi found more appropriate in this sustain release study. Loading of Imazethapyr and pH condition influence the release rate and minimum release of Imazethapyr observed at higher concentration such as 61.2% (w/w). Buffer of pH 6 found to be less favorable in terms of release of Imazethapyr from CCINC.</p>