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<p>The utilization of Poly(lactic-co-glycolic acid) (PLGA), a biocompatible and biodegradable polymer, in drug delivery systems is well established. The study utilized an economical approach to synthesize a variety of PLGA materials with different ratios between the two monomers. The study examined various types of coupling agents, different amounts of catalysts, and their respective impacts. The PLGA samples underwent evaluation for FT-IR, ¹H NMR, ¹³C NMR, GPC, viscosity, acid value, TGA, and XRD characteristics. The drug model chosen for this study was isosorbide dinitrate, which was nanoencapsulated using the solvent evaporation process and various surfactants. The nanoparticles were characterized by FT-IR, TGA, SEM, TEM, particle size, and zeta potential analyses. Drug loading capacity and encapsulation efficiency were determined, and cytotoxicity was assessed using the MTT assay on the Wi38 cell line. </p> Graphical Abstract <p></p>

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Poly(Lactic-co-glycolic acid) Nanoparticle Synthesis for Prolonged Isosorbide Dinitrate Release

  • 期刊论文

  • 发表日期：

    2026年2月16日

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  • Kholood A. Dahlous,
  • Saikh Mohammad,
  • El-Refaie Kenawy,
  • A. M. Abd El Hay,
  • Nermeen Saad,
  • Mohamed M. Azaam,
  • Ahmed Abu-Rayyan,
  • Kamel Shoueir

摘要

The utilization of Poly(lactic-co-glycolic acid) (PLGA), a biocompatible and biodegradable polymer, in drug delivery systems is well established. The study utilized an economical approach to synthesize a variety of PLGA materials with different ratios between the two monomers. The study examined various types of coupling agents, different amounts of catalysts, and their respective impacts. The PLGA samples underwent evaluation for FT-IR, ¹H NMR, ¹³C NMR, GPC, viscosity, acid value, TGA, and XRD characteristics. The drug model chosen for this study was isosorbide dinitrate, which was nanoencapsulated using the solvent evaporation process and various surfactants. The nanoparticles were characterized by FT-IR, TGA, SEM, TEM, particle size, and zeta potential analyses. Drug loading capacity and encapsulation efficiency were determined, and cytotoxicity was assessed using the MTT assay on the Wi38 cell line.

Graphical Abstract