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<p>Anti-inflammatory effect of hesperidin is constrained by low oral bioavailability, poor solubility, and degradation, while topical delivery faces challenges with skin penetration and stability. To overcome this lacuna, study was aimed to enhance transdermal delivery using nano-spanlastics, which were fabricated and reduced to the nanoscale through ultrasonication to minimize systemic side effects. Formulation was optimized using response surface method. Nano-spanlastics exhibited high entrapment efficiency (95.43 ± 0.51%), fine particle size (188.5&#xa0;nm), high negative zeta potential (-44.2 mV) and spherical nano-vesicles with well-defined boundaries and uniform morphology by scanning electron microscopy (SEM). Additionally, molecular docking study revealed effective binding of hesperidin to cyclooxygenase-2 active site with higher affinity than diclofenac. Further, gel was prepared and studied for physical properties and diffusion using in vitro and ex vivo methods. In vivo efficacy was assessed using carrageenan induced rat paw edema model. Herein, reduction in edema and paw thickness was observed as hesperidin acted on cyclooxygenase inhibitors and thus showed anti-inflammatory response. Thus, topical nano-spanlastics hesperidin loaded gel can be efficient site specific treatment of inflammation.</p>

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Topical Hesperidin Nano-Spanlastics Gel for Inflammation Relief

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Dnyanesh M. Tayade,
  • Ashlesha P. Pandit,
  • Abhijeet B. Pawar,
  • Trupti C. Deshpande,
  • Vrushali D. Kakad

摘要

Anti-inflammatory effect of hesperidin is constrained by low oral bioavailability, poor solubility, and degradation, while topical delivery faces challenges with skin penetration and stability. To overcome this lacuna, study was aimed to enhance transdermal delivery using nano-spanlastics, which were fabricated and reduced to the nanoscale through ultrasonication to minimize systemic side effects. Formulation was optimized using response surface method. Nano-spanlastics exhibited high entrapment efficiency (95.43 ± 0.51%), fine particle size (188.5 nm), high negative zeta potential (-44.2 mV) and spherical nano-vesicles with well-defined boundaries and uniform morphology by scanning electron microscopy (SEM). Additionally, molecular docking study revealed effective binding of hesperidin to cyclooxygenase-2 active site with higher affinity than diclofenac. Further, gel was prepared and studied for physical properties and diffusion using in vitro and ex vivo methods. In vivo efficacy was assessed using carrageenan induced rat paw edema model. Herein, reduction in edema and paw thickness was observed as hesperidin acted on cyclooxygenase inhibitors and thus showed anti-inflammatory response. Thus, topical nano-spanlastics hesperidin loaded gel can be efficient site specific treatment of inflammation.