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<p>Neuroinfectious diseases encompass a wide range of fungal, viral, bacterial and parasitic infections impacting the central nervous system (CNS). These lead to the critical therapeutic challenges owing to the protective nature of the blood brain barrier (BBB) and limited efficacy of conventional treatment strategies. Nanotechnology offers a promising avenue to address these challenges through the development of nanoparticles (NPs), capable of penetrating biological barriers, enhancing bioavailability (BA) and reducing systemic toxicity. This manuscript reviews the current advancements in the use of various types of NPs, like liposomes, polymeric NPs, metallic NPs and lipid-based nanocarriers, in the treatment and diagnosis of neuroinfectious diseases. Priority is placed on the mechanisms by which NPs traverse the BBB, their potential for functionalization with ligands for pathogen-specific targeting, and recent preclinical and clinical developments. The integration of nanomedicine into the management of neuroinfectious diseases holds the capacity to improve therapeutic efficacy and support the evolution of personalized and precision medicine in neurology.</p>

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Unravelling Nanotherapeutics for Treatment of Neuroinfectious Diseases

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Priyanka Sharma,
  • Mohit Kumar,
  • Neha Bajwa,
  • Thakur Gurjeet Singh,
  • Himanshu Sekhar Panda,
  • Jiban Jyoti Panda,
  • Avneet Kour

摘要

Neuroinfectious diseases encompass a wide range of fungal, viral, bacterial and parasitic infections impacting the central nervous system (CNS). These lead to the critical therapeutic challenges owing to the protective nature of the blood brain barrier (BBB) and limited efficacy of conventional treatment strategies. Nanotechnology offers a promising avenue to address these challenges through the development of nanoparticles (NPs), capable of penetrating biological barriers, enhancing bioavailability (BA) and reducing systemic toxicity. This manuscript reviews the current advancements in the use of various types of NPs, like liposomes, polymeric NPs, metallic NPs and lipid-based nanocarriers, in the treatment and diagnosis of neuroinfectious diseases. Priority is placed on the mechanisms by which NPs traverse the BBB, their potential for functionalization with ligands for pathogen-specific targeting, and recent preclinical and clinical developments. The integration of nanomedicine into the management of neuroinfectious diseases holds the capacity to improve therapeutic efficacy and support the evolution of personalized and precision medicine in neurology.