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<p>Wound healing is a complex process often hindered by microbial infections and poor drug bioavailability. Chrysin, a flavonoid with antioxidant, anti-acne, and anti-aging properties, holds immense promise for topical applications. However, its therapeutic activity is limited by poor aqueous solubility and high P-gp efflux. This study aimed to assess potential of the optimized chrysin loaded SEDDS gel in improving topical absorption, dermal permeation, and wound-healing efficacy over conventional formulations. The SEDDs formulation was systematically developed using a D-optimal mixture design, optimizing key components such as Peceol (lipid), Labrasol (surfactant), and PEG (cosolvent) to achieve an optimal particle size of 243.7&#xa0;nm ± 13&#xa0;nm and a zeta potential of -37.74 ± 7.4 mV. The optimized formulation, integrated with Carbopol 934 gel (1.5% w/w), exhibited controlled chrysin release of 86 ± 1.4% over 24&#xa0;h, ensuring sustained therapeutic action. In vivo studies in Wistar rats demonstrated accelerated wound closure, reduced inflammation, and enhanced collagen deposition, confirming the formulation’s superior wound-healing potential. By day 14, the chrysin-loaded SEDDs- based gel had nearly healed the wounds with 98.17 ± 2% of wound contraction, while the vehicle exhibited 68.75 ± 4%, standard marketed formulation (87 ± 6%), and untreated control showed only 60.4 ± 9% of wound closure. These findings underscore the effectiveness of SEDDs-loaded chrysin based gel as a promising strategy for effective topical delivery, overcoming solubility challenges while maximizing therapeutic benefits.</p> Graphical Abstract <p></p>

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Chrysin-Loaded SEDDs in Gel Matrix for Effective Wound Healing: Optimization, In Vitro Characterization and In Vivo Evaluation

  • 期刊论文

  • 发表日期：

    2025年12月19日

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  • Vishal Kumar Parida,
  • Mansi Dogra,
  • Teenu Sharma,
  • Rajan Swami,
  • Bhupinder Singh

摘要

Wound healing is a complex process often hindered by microbial infections and poor drug bioavailability. Chrysin, a flavonoid with antioxidant, anti-acne, and anti-aging properties, holds immense promise for topical applications. However, its therapeutic activity is limited by poor aqueous solubility and high P-gp efflux. This study aimed to assess potential of the optimized chrysin loaded SEDDS gel in improving topical absorption, dermal permeation, and wound-healing efficacy over conventional formulations. The SEDDs formulation was systematically developed using a D-optimal mixture design, optimizing key components such as Peceol (lipid), Labrasol (surfactant), and PEG (cosolvent) to achieve an optimal particle size of 243.7 nm ± 13 nm and a zeta potential of -37.74 ± 7.4 mV. The optimized formulation, integrated with Carbopol 934 gel (1.5% w/w), exhibited controlled chrysin release of 86 ± 1.4% over 24 h, ensuring sustained therapeutic action. In vivo studies in Wistar rats demonstrated accelerated wound closure, reduced inflammation, and enhanced collagen deposition, confirming the formulation’s superior wound-healing potential. By day 14, the chrysin-loaded SEDDs- based gel had nearly healed the wounds with 98.17 ± 2% of wound contraction, while the vehicle exhibited 68.75 ± 4%, standard marketed formulation (87 ± 6%), and untreated control showed only 60.4 ± 9% of wound closure. These findings underscore the effectiveness of SEDDs-loaded chrysin based gel as a promising strategy for effective topical delivery, overcoming solubility challenges while maximizing therapeutic benefits.

Graphical Abstract