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<p>This study aimed to evaluate the effect of the addition of starch nanocrystals (SNC) on the physicochemical and biological properties of scaffolds based on carboxymethyl cellulose and alginate containing the hydroalcoholic extract of the <i>Agaricus blazei</i> Murill mushroom. The effect of the incorporation of SNC on the physicochemical, mechanical and morphological properties of the prepared scaffolds was studied by analyzing the porosity, swelling, water uptake and retention, compressibility and contact angle. The biomaterials were characterized by spectroscopic, thermal and microscopic techniques. Finally, the biocompatibility of the scaffolds against human blood cells was evaluated. The addition of SNC and <i>Agaricus blazei</i> Murill extract corroborated the increase in porosity, swelling degree, absorptive capacity, physical resistance and thermal stability of the formulations. On the other hand, it corroborated the reduction of the matrix wettability. The determination of the hemolysis index, as well as the study of metabolic activity and release of the enzyme lactate dehydrogenase in human platelets, indicated that the prepared formulations are hemocompatible. Together with the cell adhesion study, these results indicate that the developed biomaterials have potential for tissue repair.</p>

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Effect of Starch Nanocrystals on Physicochemical Properties and Cytocompatibility of Carboxymethyl Cellulose/Alginate-based Scaffolds Loaded with Agaricus blazei Murill Extract

  • 期刊论文

  • 发表日期：

    2025年12月17日

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  • Matheus da Silva Campelo,
  • João Francisco Câmara Neto,
  • Antônio Emanuel de Jesus Freires,
  • Adriano Lincoln Albuquerque Mattos,
  • Nágila Maria Pontes Silva Ricardo,
  • Luzia Kalyne Almeida Moreira Leal,
  • Maria Elenir Nobre Pinho Ribeiro

摘要

This study aimed to evaluate the effect of the addition of starch nanocrystals (SNC) on the physicochemical and biological properties of scaffolds based on carboxymethyl cellulose and alginate containing the hydroalcoholic extract of the Agaricus blazei Murill mushroom. The effect of the incorporation of SNC on the physicochemical, mechanical and morphological properties of the prepared scaffolds was studied by analyzing the porosity, swelling, water uptake and retention, compressibility and contact angle. The biomaterials were characterized by spectroscopic, thermal and microscopic techniques. Finally, the biocompatibility of the scaffolds against human blood cells was evaluated. The addition of SNC and Agaricus blazei Murill extract corroborated the increase in porosity, swelling degree, absorptive capacity, physical resistance and thermal stability of the formulations. On the other hand, it corroborated the reduction of the matrix wettability. The determination of the hemolysis index, as well as the study of metabolic activity and release of the enzyme lactate dehydrogenase in human platelets, indicated that the prepared formulations are hemocompatible. Together with the cell adhesion study, these results indicate that the developed biomaterials have potential for tissue repair.