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<p>We report the results on hyperthermia of the antibiotic-resistant “ESKAPE” group bacteria: gram-positive <i>S. aureus</i>,<i> S. epidermidis</i> and gram-negative <i>P. aeruginosa</i>,<i> E. coli</i>,<i> K. pneumoniae</i>. It was shown that the application of colloidal Gd<sub>2</sub>O<sub>3</sub>:Yb nanoparticles with their subsequent exposure to near-IR radiation leads to the destruction of bacterial membranes and disruption of the secondary structure of proteins, which leads to complete liquid sterilization. Laser-ablative processing of Gd<sub>2</sub>O<sub>3</sub>:Yb micropowder was carried out using IR laser systems (1064&#xa0;nm, 1030&#xa0;nm) with nano- and femtosecond pulse durations to synthesize nanoparticles. According to the data obtained, the optimal regime for the nanoparticles’ formation was femtosecond ablation (the average particle diameter of the lesser fraction equaled 10–30&#xa0;nm). Nanoparticles were characterized by scanning electron and transmission microscopy, energy-dispersive X-ray spectroscopy and infrared spectroscopy.</p>

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Membrane Destruction and Proteins’ Denaturation in Pathogenic Bacteria Via Gd2O3:Yb Nanoparticles-Based Hyperthermia

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Irina Saraeva,
  • Dmitrii Shcherbinin,
  • Dmitrii Bulyga,
  • Eteri Tolordava,
  • Andrey Rudenko,
  • Dmitrii Khmelenin,
  • Roman Khmelnitskii,
  • Darya Pozdnyakova,
  • Sergey Kudryashov,
  • Andrei Ivanov

摘要

We report the results on hyperthermia of the antibiotic-resistant “ESKAPE” group bacteria: gram-positive S. aureus, S. epidermidis and gram-negative P. aeruginosa, E. coli, K. pneumoniae. It was shown that the application of colloidal Gd2O3:Yb nanoparticles with their subsequent exposure to near-IR radiation leads to the destruction of bacterial membranes and disruption of the secondary structure of proteins, which leads to complete liquid sterilization. Laser-ablative processing of Gd2O3:Yb micropowder was carried out using IR laser systems (1064 nm, 1030 nm) with nano- and femtosecond pulse durations to synthesize nanoparticles. According to the data obtained, the optimal regime for the nanoparticles’ formation was femtosecond ablation (the average particle diameter of the lesser fraction equaled 10–30 nm). Nanoparticles were characterized by scanning electron and transmission microscopy, energy-dispersive X-ray spectroscopy and infrared spectroscopy.