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<p>Nanotechnology offers synthesis of nanoparticles by unique combination of metals and natural or synthetic products with improved drug delivery for therapeutic uses. <b>The goal of this study was to synthesize tiron functionalized silver nanoparticles (TAgNPs) with physicochemical profiling and biological properties for nanomedicine applications.</b> Synthesis of TAgNPs was confirmed by change in color to golden yellow with peak range of 430–440&#xa0;nm under UV-visible spectroscopy. The particle size was found in the range of nanoscale with a spherical shape under electron microscopy. Crystalline phase of tiron functionalized silver nanoparticles was observed by X-ray powder diffraction and thermal stability was confirmed by thermogravimetric analysis. Functional groups were validated under FTIR spectroscopy, which quantified functional groups on the surfaces of TAgNPs. The ability of TAgNPs to scavenge free radicals was evaluated with H<sub>2</sub>O<sub>2,</sub> DPPH and ABTS assays, which suggested its excellent antioxidant potential. In vitro cytoprotective and geno-protective potential suggested outstanding safety profile of TAgNPs. Thus, tiron functionalized silver nanoparticles have physico-chemical and biological properties as a nanomedicine against oxidative stress associated toxic manifestations or disorders.</p>

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Tiron Functionalized Silver Nanoparticles: Physicochemical Profiling and Biological Properties for Nanomedicine Applications

  • 期刊论文

  • 发表日期：

    2025年12月17日

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  • Pratima Dutta,
  • Satendra Kumar Nirala,
  • Pavitra Behra,
  • Asim Amitabh Sahu,
  • Ankita Mukherjee,
  • Monika Bhadauria

摘要

Nanotechnology offers synthesis of nanoparticles by unique combination of metals and natural or synthetic products with improved drug delivery for therapeutic uses. The goal of this study was to synthesize tiron functionalized silver nanoparticles (TAgNPs) with physicochemical profiling and biological properties for nanomedicine applications. Synthesis of TAgNPs was confirmed by change in color to golden yellow with peak range of 430–440 nm under UV-visible spectroscopy. The particle size was found in the range of nanoscale with a spherical shape under electron microscopy. Crystalline phase of tiron functionalized silver nanoparticles was observed by X-ray powder diffraction and thermal stability was confirmed by thermogravimetric analysis. Functional groups were validated under FTIR spectroscopy, which quantified functional groups on the surfaces of TAgNPs. The ability of TAgNPs to scavenge free radicals was evaluated with H2O2, DPPH and ABTS assays, which suggested its excellent antioxidant potential. In vitro cytoprotective and geno-protective potential suggested outstanding safety profile of TAgNPs. Thus, tiron functionalized silver nanoparticles have physico-chemical and biological properties as a nanomedicine against oxidative stress associated toxic manifestations or disorders.