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<p>The rise of antifungal resistance in dermatophytosis underscores the need for novel antifungals, driving green synthesis of zinc oxide nanoparticles (ZnO NPs). In this study, we report extracellular biosynthesis of ZnO NPs using a clinical isolate, <i>Candida albicans</i> CA26, and evaluate their physicochemical properties, antioxidant capacity, and antifungal efficacy against <i>Nannizzia incurvata</i> TI03. The biosynthesized ZnO NPs were characterized via UV-Vis, FTIR, XRD, TEM, BET, DLS and zeta potential analyses, confirming their crystalline nature, rod-to-bar morphology, and biomolecular capping. DPPH, ABTS, nitric oxide, hydroxyl radical, and superoxide assays showed moderate yet significant antioxidant activity. The antifungal efficacy against <i>N. incurvata</i> TI03 showed potent inhibition, with activity comparable to azoles. The biosynthesized ZnO NPs thus exhibited multimodal antifungal mechanisms, likely involving reactive oxygen species generation, membrane disruption, and enzyme inhibition, in addition to their antioxidant activity. These findings suggest that CA26-derived ZnO NPs could be developed as eco-friendly topical antifungal agents with added antioxidant potential.</p>

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Green Synthesis of ZnO Nanoparticles Using Candida albicans CA26: Antioxidant and Antifungal Activity against Nannizzia incurvata

  • 期刊论文

  • 发表日期：

    2025年10月27日

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  • Yajurved N Selokar,
  • Parameswaran Sree Pranav,
  • Rakesh U Thakare

摘要

The rise of antifungal resistance in dermatophytosis underscores the need for novel antifungals, driving green synthesis of zinc oxide nanoparticles (ZnO NPs). In this study, we report extracellular biosynthesis of ZnO NPs using a clinical isolate, Candida albicans CA26, and evaluate their physicochemical properties, antioxidant capacity, and antifungal efficacy against Nannizzia incurvata TI03. The biosynthesized ZnO NPs were characterized via UV-Vis, FTIR, XRD, TEM, BET, DLS and zeta potential analyses, confirming their crystalline nature, rod-to-bar morphology, and biomolecular capping. DPPH, ABTS, nitric oxide, hydroxyl radical, and superoxide assays showed moderate yet significant antioxidant activity. The antifungal efficacy against N. incurvata TI03 showed potent inhibition, with activity comparable to azoles. The biosynthesized ZnO NPs thus exhibited multimodal antifungal mechanisms, likely involving reactive oxygen species generation, membrane disruption, and enzyme inhibition, in addition to their antioxidant activity. These findings suggest that CA26-derived ZnO NPs could be developed as eco-friendly topical antifungal agents with added antioxidant potential.