Scholarlink

<p>This study evaluates the cardioprotective potential of <i>Pandanus amaryllifolius</i> leaf extract and its phytosomal formulation against azithromycin-induced cardiotoxicity in Wistar rats. Phytochemical analysis via LC–MS identified bioactive compounds including kaempferol and pandamarine. Antioxidant potential was confirmed through DPPH assay (IC₅₀ = 72.9&#xa0;µg/mL), total phenolic content (34.42&#xa0;mg GAE/g), and total flavonoid content (17.85&#xa0;mg QE/g). Phytosomes were optimized for particle size (253.9&#xa0;nm) and zeta potential (− 0.53&#xa0;mV) and characterized using FTIR and TEM. Rats received azithromycin (30&#xa0;mg/kg) with or without extract (100, 200, 400&#xa0;mg/kg) or phytosomal formulation. Azithromycin elevated QT interval, heart weight, serum CK-MB, LDH, lipid profile, and malondialdehyde, while reducing SOD, GSH, and HDL levels. Both extract and formulation significantly restored ECG parameters, antioxidant enzyme activity, lipid profile, and reduced myocardial damage, with the phytosomal formulation showing superior effects. Histopathology confirmed preservation of myocardial architecture in treated groups, particularly with phytosomes. Findings suggest <i>Pandanus amaryllifolius</i> exerts cardioprotection via antioxidant, anti-inflammatory, and lipid-lowering mechanisms, enhanced by phytosomal delivery. This natural therapeutic shows promise in preventing drug-induced cardiotoxicity, warranting further molecular and clinical evaluation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Development of Phytosome Loaded with Pandanus amaryllifolius Roxb Extract with its LC–MS Approach against Azithromycin Induced Cardiotoxicity in Rats

  • 期刊论文

  • 发表日期：

    2025年10月27日

查看全文
  • Sarvesh Havaldar,
  • Namit Kudatarkar

摘要

This study evaluates the cardioprotective potential of Pandanus amaryllifolius leaf extract and its phytosomal formulation against azithromycin-induced cardiotoxicity in Wistar rats. Phytochemical analysis via LC–MS identified bioactive compounds including kaempferol and pandamarine. Antioxidant potential was confirmed through DPPH assay (IC₅₀ = 72.9 µg/mL), total phenolic content (34.42 mg GAE/g), and total flavonoid content (17.85 mg QE/g). Phytosomes were optimized for particle size (253.9 nm) and zeta potential (− 0.53 mV) and characterized using FTIR and TEM. Rats received azithromycin (30 mg/kg) with or without extract (100, 200, 400 mg/kg) or phytosomal formulation. Azithromycin elevated QT interval, heart weight, serum CK-MB, LDH, lipid profile, and malondialdehyde, while reducing SOD, GSH, and HDL levels. Both extract and formulation significantly restored ECG parameters, antioxidant enzyme activity, lipid profile, and reduced myocardial damage, with the phytosomal formulation showing superior effects. Histopathology confirmed preservation of myocardial architecture in treated groups, particularly with phytosomes. Findings suggest Pandanus amaryllifolius exerts cardioprotection via antioxidant, anti-inflammatory, and lipid-lowering mechanisms, enhanced by phytosomal delivery. This natural therapeutic shows promise in preventing drug-induced cardiotoxicity, warranting further molecular and clinical evaluation.