Scholarlink

<p>Drug nanocarriers offer an effective approach to reduce off-target toxicity in cancer therapy. Zeolitic imidazolate frameworks (ZIFs) are promising drug carriers due to their unique properties. In this study, we synthesized CoFe<sub>2</sub>O<sub>4</sub>@ZIF-67 core–shell nanocomposite via co-precipitation under an ammonia atmosphere at 25&#xa0;°C and loaded it with DOX at various concentrations. The CoFe<sub>2</sub>O<sub>4</sub>@ZIF-67 nanohybrid achieved high drug loading efficiencies of 98.6% (50&#xa0;ppm) and 98.2% (500&#xa0;ppm), surpassing CoFe<sub>2</sub>O<sub>4</sub> (94.1% at 500&#xa0;ppm) and ZIF-67 (96.2% at 500&#xa0;ppm). Drug release was evaluated in saline phosphate buffer at pH 7.4 and 5.5 at 37&#xa0;°C for 168&#xa0;h using a UV–Vis spectrophotometer. At 500&#xa0;ppm, release rates for CoFe<sub>2</sub>O<sub>4</sub>@ZIF-67@DOX were 28.4% at pH 7.4 and 36.07% at pH 5.5, compared to CoFe<sub>2</sub>O<sub>4</sub>@DOX (39.8% at pH 7.4, 24.25% at pH 5.5) and ZIF-67@DOX (19.7% at pH 7.4, 33.4% at pH 5.5). These results highlight the CoFe<sub>2</sub>O<sub>4</sub>@ZIF-67@DOX nanohybrid’s superior drug loading and controlled release, making it a promising candidate for targeted drug delivery. All synthesized nanostructures were identified using infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), BET analysis, and thermogravimetric analysis (TGA).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Novel Approach to Synthesis of CoFe2O4@ZIF-67 Nanohybrid and its Potential as a Controlled Release System of Doxorubicin Drug

  • 期刊论文

  • 发表日期：

    2025年9月19日

查看全文
  • Zahra Khomami,
  • Mohammadreza Mansournia

摘要

Drug nanocarriers offer an effective approach to reduce off-target toxicity in cancer therapy. Zeolitic imidazolate frameworks (ZIFs) are promising drug carriers due to their unique properties. In this study, we synthesized CoFe2O4@ZIF-67 core–shell nanocomposite via co-precipitation under an ammonia atmosphere at 25 °C and loaded it with DOX at various concentrations. The CoFe2O4@ZIF-67 nanohybrid achieved high drug loading efficiencies of 98.6% (50 ppm) and 98.2% (500 ppm), surpassing CoFe2O4 (94.1% at 500 ppm) and ZIF-67 (96.2% at 500 ppm). Drug release was evaluated in saline phosphate buffer at pH 7.4 and 5.5 at 37 °C for 168 h using a UV–Vis spectrophotometer. At 500 ppm, release rates for CoFe2O4@ZIF-67@DOX were 28.4% at pH 7.4 and 36.07% at pH 5.5, compared to CoFe2O4@DOX (39.8% at pH 7.4, 24.25% at pH 5.5) and ZIF-67@DOX (19.7% at pH 7.4, 33.4% at pH 5.5). These results highlight the CoFe2O4@ZIF-67@DOX nanohybrid’s superior drug loading and controlled release, making it a promising candidate for targeted drug delivery. All synthesized nanostructures were identified using infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), BET analysis, and thermogravimetric analysis (TGA).