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<p>Amid the ongoing challenges faced by traditional cancer therapies, the use of nanomaterials as smart carriers for beta-minus-emitting radionuclides has emerged as a promising approach for targeted cancer treatment. In this study, gold nanoparticles (Au NPs) were fabricated by a plasma jet system using gold salts at a concentration of 0.6&#xa0;mM and loading them with negative beta particles at doses of 1.2 KGy, 14.4 KGy, and 15.6 KGy. The following tests were performed: FE-SEM, XRD, and UV. The UV peaks were located between 680 and 720&#xa0;nm, and the XRD values for Au were 38.76 (111), 44.4 (200), and 77.5 (311), along with the impact on the MDA cell line for breast cancer.After 48&#xa0;h, the maximal growth inhibition of AuNPs irradiated 15.6 KGy was 60 %. After 48&#xa0;h of exposure to 14.4 KGy of AuNPs, the normal cell line (REF) showed the highest toxicity of 15.3%. The greatest value in inhibiting the cancer cell line (MDA-MB-231) for the combined treatment of AuNPs irradiated 15.6 KGy and 35&#xa0;µg of Adriamycin chemotherapy was 74.33 %. At the same time, the greatest toxicity of the combined treatment was 27.66%.</p>

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Inhibition of Breast Cancer MDA Cells Line with Gold Nanoparticles Loaded by Beta Particles and Adriamycin Chemo Therapy

  • 期刊论文

  • 发表日期：

    2025年12月17日

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  • Sala Sami Hamza,
  • Ruwiadah Tarek Mahdi,
  • Ban H. Adil,
  • Ban Sabah Hameed,
  • Ahmed S. Obaid

摘要

Amid the ongoing challenges faced by traditional cancer therapies, the use of nanomaterials as smart carriers for beta-minus-emitting radionuclides has emerged as a promising approach for targeted cancer treatment. In this study, gold nanoparticles (Au NPs) were fabricated by a plasma jet system using gold salts at a concentration of 0.6 mM and loading them with negative beta particles at doses of 1.2 KGy, 14.4 KGy, and 15.6 KGy. The following tests were performed: FE-SEM, XRD, and UV. The UV peaks were located between 680 and 720 nm, and the XRD values for Au were 38.76 (111), 44.4 (200), and 77.5 (311), along with the impact on the MDA cell line for breast cancer.After 48 h, the maximal growth inhibition of AuNPs irradiated 15.6 KGy was 60 %. After 48 h of exposure to 14.4 KGy of AuNPs, the normal cell line (REF) showed the highest toxicity of 15.3%. The greatest value in inhibiting the cancer cell line (MDA-MB-231) for the combined treatment of AuNPs irradiated 15.6 KGy and 35 µg of Adriamycin chemotherapy was 74.33 %. At the same time, the greatest toxicity of the combined treatment was 27.66%.