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<p>Wound healing is a complicated process that involves diverse phases, including cellular, molecular, and tissue-level facets. Efficient wound recovery is one of the challenging aspects for humans to sustain themselves against the outer environment. This research work involves wound healing assessment of polymer-functionalized manganese oxide nanoparticles (Mn<sub>3</sub>O<sub>4</sub> NPs). Polyethylene glycol (PEG) and polyethyleneimine (PEI) coated Mn<sub>3</sub>O<sub>4</sub> NPs were synthesized using the hydrothermal process. SEM micrographs indicate the nanomaterials had a spherical shape and grain sizes of 77 ± 18&#xa0;nm, 68 ± 20&#xa0;nm, and 85 ± 17&#xa0;nm for bare, PEG, and PEI functionalized Mn<sub>3</sub>O<sub>4</sub> NPs, respectively. The antibacterial properties were examined against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> bacterial strains. Mn<sub>3</sub>O<sub>4</sub> NPs have demonstrated improved antibacterial activity against <i>S. aureus</i> and <i>E. coli</i>. Alginate gels containing NPs have shown improved wound recovery in <i>Gallus gallus domesticus</i>. PEGylated Mn<sub>3</sub>O<sub>4</sub> NPs have demonstrated a quicker wound-healing mechanism in <i>G. domesticus</i> than bare Mn<sub>3</sub>O<sub>4</sub> NPs. During biochemical and histological analysis, residual toxicity and inflammation are not seen in the liver, heart, and lungs. Our findings showed that modifying the surfaces with PEG and PEI can increase the wound-healing potential of Mn<sub>3</sub>O<sub>4</sub> NPs.</p> Graphical Abstract <p></p>

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Polymer-Modified Manganese Oxide Nanoparticlesfor Enhanced Wound Healing Properties

  • 期刊论文

  • 发表日期：

    2025年9月29日

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  • Muhammad Nazim Hussain,
  • Muhammad Khawar Abbas,
  • Naveed Akhtar Shad,
  • Asmat Ullah,
  • Amna Bashir,
  • Saman Ishfaq,
  • Muhammad Zulqarnain,
  • Syed Fazel Bin Farukh,
  • Yasir Javed

摘要

Wound healing is a complicated process that involves diverse phases, including cellular, molecular, and tissue-level facets. Efficient wound recovery is one of the challenging aspects for humans to sustain themselves against the outer environment. This research work involves wound healing assessment of polymer-functionalized manganese oxide nanoparticles (Mn3O4 NPs). Polyethylene glycol (PEG) and polyethyleneimine (PEI) coated Mn3O4 NPs were synthesized using the hydrothermal process. SEM micrographs indicate the nanomaterials had a spherical shape and grain sizes of 77 ± 18 nm, 68 ± 20 nm, and 85 ± 17 nm for bare, PEG, and PEI functionalized Mn3O4 NPs, respectively. The antibacterial properties were examined against Staphylococcus aureus and Escherichia coli bacterial strains. Mn3O4 NPs have demonstrated improved antibacterial activity against S. aureus and E. coli. Alginate gels containing NPs have shown improved wound recovery in Gallus gallus domesticus. PEGylated Mn3O4 NPs have demonstrated a quicker wound-healing mechanism in G. domesticus than bare Mn3O4 NPs. During biochemical and histological analysis, residual toxicity and inflammation are not seen in the liver, heart, and lungs. Our findings showed that modifying the surfaces with PEG and PEI can increase the wound-healing potential of Mn3O4 NPs.

Graphical Abstract