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<p>Seborrheic dermatitis (SD) is a chronic inflammatory skin condition characterized by erythema, scaling, and discomfort, commonly associated with <i>Malassezia</i> yeast overgrowth. Traditional therapies frequently have side effects and do not offer long-term relief. The purpose of this work is to develop a novel Liposomal serum loaded with Berberine HCl for the topical treatment of SD. Using the active loading approach, Liposomes were developed using cholesterol and phospholipid 90H. The prepared liposomes were then added to a serum base using ammonium acryloyldimethyltaurate copolymer (Aristoflex AVC). The developed formulation was evaluated for particle size, zeta potential, entrapment efficiency, pH, viscosity, spreadability, textural profile, drug content, and in vitro diffusion study. The optimized formulation (LS10) was evaluated for its physicochemical characteristics: it exhibited a nanoscale particle size of 154.2 ± 3.4&#xa0;nm, zeta potential of −32.6 ± 1.8&#xa0;mV, entrapment efficiency of 92.3 ± 2.1%, viscosity of 6240 mPas, pH of 5.8 ± 0.2, spreadability of 6.9 ± 0.3&#xa0;cm, and firmness of 17.4 ± 0.9&#xa0;g. In vitro diffusion studies demonstrated sustained drug release up to 89.5% over 24&#xa0;h, while ex vivo permeation data confirmed enhanced skin permeation with a flux of 1.27&#xa0;µg/cm<sup>2</sup>/h and a permeability coefficient of 3.81 × 10⁻<sup>3</sup>&#xa0;cm/h. These characteristics underscore its potential for enhanced cutaneous delivery, controlled drug release, and improved patient compliance. Moreover, the formulation remained physically stable under accelerated storage conditions for 30&#xa0;days. Thus, the developed Berberine-loaded liposomal serum offers a promising alternative for the topical management of SD by improving drug penetration, retention, and tolerability compared to conventional treatments.</p> Graphical Abstract <p></p>

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Berberine HCl-Loaded Liposomal Nanoformulation for the Topical Treatment of Seborrheic Dermatitis

  • 期刊论文

  • 发表日期：

    2025年12月17日

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  • Simran Raj,
  • Geeta Patel

摘要

Seborrheic dermatitis (SD) is a chronic inflammatory skin condition characterized by erythema, scaling, and discomfort, commonly associated with Malassezia yeast overgrowth. Traditional therapies frequently have side effects and do not offer long-term relief. The purpose of this work is to develop a novel Liposomal serum loaded with Berberine HCl for the topical treatment of SD. Using the active loading approach, Liposomes were developed using cholesterol and phospholipid 90H. The prepared liposomes were then added to a serum base using ammonium acryloyldimethyltaurate copolymer (Aristoflex AVC). The developed formulation was evaluated for particle size, zeta potential, entrapment efficiency, pH, viscosity, spreadability, textural profile, drug content, and in vitro diffusion study. The optimized formulation (LS10) was evaluated for its physicochemical characteristics: it exhibited a nanoscale particle size of 154.2 ± 3.4 nm, zeta potential of −32.6 ± 1.8 mV, entrapment efficiency of 92.3 ± 2.1%, viscosity of 6240 mPas, pH of 5.8 ± 0.2, spreadability of 6.9 ± 0.3 cm, and firmness of 17.4 ± 0.9 g. In vitro diffusion studies demonstrated sustained drug release up to 89.5% over 24 h, while ex vivo permeation data confirmed enhanced skin permeation with a flux of 1.27 µg/cm2/h and a permeability coefficient of 3.81 × 10⁻3 cm/h. These characteristics underscore its potential for enhanced cutaneous delivery, controlled drug release, and improved patient compliance. Moreover, the formulation remained physically stable under accelerated storage conditions for 30 days. Thus, the developed Berberine-loaded liposomal serum offers a promising alternative for the topical management of SD by improving drug penetration, retention, and tolerability compared to conventional treatments.

Graphical Abstract