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<p>Fluconazole-loaded solid lipid nanoparticles and clindamycin niosomes were integrated into six soft denture liners (five liners, one tissue conditioner) to enhance the antimicrobial drug delivery system. A total of 144 acrylic blocks (10 × 10 × 20&#xa0;mm) with 3&#xa0;mm liners were prepared, testing drug-loaded and control groups. FT-IR analysis identified functional groups, while universal testing measured bond strength between liners and denture bases. Nanoparticle sizing and zeta potential were assessed via Horiba SZ-100 instruments, with statistical analysis validating efficacy. The FT-IR peaks indicated lipid composition and interactions, revealing aliphatic hydrocarbons and carbonyl groups. The mean of maximum applied force (F<sub>max</sub>), tension created in the structure (dL at F<sub>max</sub>), and maximum tension in the breakpoint (dL at break) were 39.38 ± 26.06 N, 2.509 ± 1.68&#xa0;mm, and 4.44 ± 2.94&#xa0;mm, respectively. The lowest recorded force was about GC soft-liner loaded with niosome (11.92 ± 6.71 N), and the highest registered force was about the Voco soft-liner (94.57 ± 30.86 N) as a control. The maximum force withstood by cases was about Mollosil soft-liner loaded with SLN (48.22 ± 14.87). The comparison of applied force tensile bond strength showed mean values for various groups.</p> Graphical Abstract <p></p>

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Soft Liners Loaded with Fluconazole Solid Lipid Nanoparticles (SLNs) and Clindamycin Niosomes as Drug Delivery Systems

  • 期刊论文

  • 发表日期：

    2025年9月4日

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  • Hesam Hosseinzadeh,
  • Reza Derafshi,
  • Farhad Mohammadi,
  • Farzaneh Abazari,
  • Maryam Hosseinzadeh,
  • Rashin Giti

摘要

Fluconazole-loaded solid lipid nanoparticles and clindamycin niosomes were integrated into six soft denture liners (five liners, one tissue conditioner) to enhance the antimicrobial drug delivery system. A total of 144 acrylic blocks (10 × 10 × 20 mm) with 3 mm liners were prepared, testing drug-loaded and control groups. FT-IR analysis identified functional groups, while universal testing measured bond strength between liners and denture bases. Nanoparticle sizing and zeta potential were assessed via Horiba SZ-100 instruments, with statistical analysis validating efficacy. The FT-IR peaks indicated lipid composition and interactions, revealing aliphatic hydrocarbons and carbonyl groups. The mean of maximum applied force (Fmax), tension created in the structure (dL at Fmax), and maximum tension in the breakpoint (dL at break) were 39.38 ± 26.06 N, 2.509 ± 1.68 mm, and 4.44 ± 2.94 mm, respectively. The lowest recorded force was about GC soft-liner loaded with niosome (11.92 ± 6.71 N), and the highest registered force was about the Voco soft-liner (94.57 ± 30.86 N) as a control. The maximum force withstood by cases was about Mollosil soft-liner loaded with SLN (48.22 ± 14.87). The comparison of applied force tensile bond strength showed mean values for various groups.

Graphical Abstract