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<p>Rabbit mange is a contagious disease that causes serious financial losses, such as decreased productivity, weight loss, drug costs, and mortality. Nanotechnology enables treatment of many diseases by delivering drugs directly to the target cells. Despite using various topical medications for rabbit mites, none showed satisfactory results, and some caused irritation or had long withdrawal times. Therefore, the current study aimed to explore a novel nanomedication for sarcoptic mange in rabbits using topical application of chitosan-coated zinc oxide nanoparticles (CS-ZnO NPs). Thirty-five young rabbits were used; seven rabbits were kept as a control negative group, while the remaining rabbits were naturally infested with sarcoptic mange and then divided into four groups (<i>n</i> = 7 for each). Group I did not receive any treatments, group II was treated with a single s/c injection of ivermectin 1% (0.4&#xa0;mg/kg bwt), group III was treated with topical application of CS-ZnO NPs (100&#xa0;ppm) 3 times a week for 2&#xa0;weeks, and group IV was treated with a mixture of ivermectin 1% + CS-ZnO NPs as the same protocol dosing. The results revealed that the topical application of CS-ZnO NPs, either alone or combined with ivermectin, significantly reduced the number of adults and improved skin lesions of the infected rabbits, unlike the use of ivermectin alone which had a low recovery rate and high mortality rate. The topical application of CS-ZnO NPs also downregulated the inflammatory markers Cox-2 and TNF-α within skin tissues, indicating its potent anti-inflammatory activity.</p>

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Therapeutic Efficacy of Chitosan-Coated Zinc Oxide Nanoparticles Against Sarcoptic Mange in Rabbits

  • 期刊论文

  • 发表日期：

    2025年8月20日

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  • Ahmed A. Sherif,
  • Eman I. Hassanen,
  • Mai Abuowarda,
  • Rawhia Doghaim

摘要

Rabbit mange is a contagious disease that causes serious financial losses, such as decreased productivity, weight loss, drug costs, and mortality. Nanotechnology enables treatment of many diseases by delivering drugs directly to the target cells. Despite using various topical medications for rabbit mites, none showed satisfactory results, and some caused irritation or had long withdrawal times. Therefore, the current study aimed to explore a novel nanomedication for sarcoptic mange in rabbits using topical application of chitosan-coated zinc oxide nanoparticles (CS-ZnO NPs). Thirty-five young rabbits were used; seven rabbits were kept as a control negative group, while the remaining rabbits were naturally infested with sarcoptic mange and then divided into four groups (n = 7 for each). Group I did not receive any treatments, group II was treated with a single s/c injection of ivermectin 1% (0.4 mg/kg bwt), group III was treated with topical application of CS-ZnO NPs (100 ppm) 3 times a week for 2 weeks, and group IV was treated with a mixture of ivermectin 1% + CS-ZnO NPs as the same protocol dosing. The results revealed that the topical application of CS-ZnO NPs, either alone or combined with ivermectin, significantly reduced the number of adults and improved skin lesions of the infected rabbits, unlike the use of ivermectin alone which had a low recovery rate and high mortality rate. The topical application of CS-ZnO NPs also downregulated the inflammatory markers Cox-2 and TNF-α within skin tissues, indicating its potent anti-inflammatory activity.