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<p>In recent years, using nanoparticles (NPs) to combat bacterial growth has gained significant attention, presenting a promising alternative to conventional antibiotics. Iron oxide nanoparticles (INPs) have gained attention in nanotechnology and biological applications due to their enhanced biocompatibility and effectiveness. This study highlights the green synthesis of quercetagetin-mediated iron oxide nanoparticles (QTG-INPs) for enhanced antibacterial activity against <i>Staphylococcus aureus</i>. QTG-INPs were characterized using ultraviolet–visible (UV–Vis) spectroscopy, dynamic light scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, and atomic force microscopy (AFM). The synthesized INPs exhibited a predominantly spherical shape morphology with 144.8 ± 3.25 nm average size and showed UV–Vis absorption at approximately 278 nm. Their antioxidant potential was assessed via DPPH and ABTS assays, while antimicrobial activity against <i>Staphylococcus aureus</i> was evaluated using the well diffusion method. QTG-INPs displayed significant antioxidant activity, with IC<sub>50</sub> values of 15.22 ± 2.32 μg/mL for DPPH (vs. ascorbic acid) and 19.40 ± 2.84 μg/mL for ABTS (vs. Trolox). Additionally, antibacterial analysis showed a notable decrease in both MIC and IC<sub>50</sub> values for QTG-INPs compared to QTG alone, highlighting their potential as an effective alternative for combating bacterial infections.</p>

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Green Synthesis of Quercetagetin-Stabilized Iron Oxide Nanoparticles for Enhanced Antioxidant and Antibacterial Properties

  • 期刊论文

  • 发表日期：

    2025年8月2日

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  • Wajeeha Muzafar,
  • Tasmina Kanwal,
  • Khadija Rehman,
  • Samina Perveen,
  • Fayazullah Khan,
  • Syed Hasnain Ali Naqvi,
  • Shaheen Faizi,
  • Muhammad Raza Shah

摘要

In recent years, using nanoparticles (NPs) to combat bacterial growth has gained significant attention, presenting a promising alternative to conventional antibiotics. Iron oxide nanoparticles (INPs) have gained attention in nanotechnology and biological applications due to their enhanced biocompatibility and effectiveness. This study highlights the green synthesis of quercetagetin-mediated iron oxide nanoparticles (QTG-INPs) for enhanced antibacterial activity against Staphylococcus aureus. QTG-INPs were characterized using ultraviolet–visible (UV–Vis) spectroscopy, dynamic light scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, and atomic force microscopy (AFM). The synthesized INPs exhibited a predominantly spherical shape morphology with 144.8 ± 3.25 nm average size and showed UV–Vis absorption at approximately 278 nm. Their antioxidant potential was assessed via DPPH and ABTS assays, while antimicrobial activity against Staphylococcus aureus was evaluated using the well diffusion method. QTG-INPs displayed significant antioxidant activity, with IC50 values of 15.22 ± 2.32 μg/mL for DPPH (vs. ascorbic acid) and 19.40 ± 2.84 μg/mL for ABTS (vs. Trolox). Additionally, antibacterial analysis showed a notable decrease in both MIC and IC50 values for QTG-INPs compared to QTG alone, highlighting their potential as an effective alternative for combating bacterial infections.