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<p>The majority of researchers agree that natural medicines have better anti-aging, anti-tumor, and anti-inflammatory effects. Following π-π aggregation with the cyanine fluorescent label IR-813 and the macroconjugated structure system of emodin, we used hydrogenated soybean phospholipid to encapsulate the double liposome nanofluorescent complex (EIHP) in oil–water. The size of the nanoparticle was measured by the particle size analyzer at around 221.7&#xa0;nm, and the ZETA potential was determined at 21.9&#xa0;mV. In accordance with the findings of transmission electron microscopy (TEM), these results demonstrated that the nanoparticle tended to be in a stable state and had good dispersion. This resulted from the fluorescent complex’s solid phospholipid encapsulation in the center. The release curve of EIHP in the gastrointestinal environment was significantly changed at pH values of 5, 6, and 7, with an upward trend, especially at pH values of 5 and 7. In the cytotoxicity study, when the concentration of EIHP reached 60&#xa0;μg/mL, the HCT-116 cell proliferation rate increased to 74.2%. EIHP may be toxic to HCT-116 cells and have a high capacity for proliferation. The high biological activity of EIHP is closely related to targeting and biocompatibility in cell imaging.</p>

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Preparation, Sustained Release, and Biological Activity Study of a Novel IR-813/Emodin Nanofluorescent Complex

  • 期刊论文

  • 发表日期：

    2025年7月3日

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  • Bo Xue,
  • Jianpeng Hu,
  • Jiang Zhenhua,
  • Feng Jin

摘要

The majority of researchers agree that natural medicines have better anti-aging, anti-tumor, and anti-inflammatory effects. Following π-π aggregation with the cyanine fluorescent label IR-813 and the macroconjugated structure system of emodin, we used hydrogenated soybean phospholipid to encapsulate the double liposome nanofluorescent complex (EIHP) in oil–water. The size of the nanoparticle was measured by the particle size analyzer at around 221.7 nm, and the ZETA potential was determined at 21.9 mV. In accordance with the findings of transmission electron microscopy (TEM), these results demonstrated that the nanoparticle tended to be in a stable state and had good dispersion. This resulted from the fluorescent complex’s solid phospholipid encapsulation in the center. The release curve of EIHP in the gastrointestinal environment was significantly changed at pH values of 5, 6, and 7, with an upward trend, especially at pH values of 5 and 7. In the cytotoxicity study, when the concentration of EIHP reached 60 μg/mL, the HCT-116 cell proliferation rate increased to 74.2%. EIHP may be toxic to HCT-116 cells and have a high capacity for proliferation. The high biological activity of EIHP is closely related to targeting and biocompatibility in cell imaging.