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<p>Multifunctional electrospun scaffolds are pivotal in advancing tissue engineering and wound healing applications. In this study, electrospun polycaprolactone (PCL) nanocomposite scaffolds incorporating cerium oxide (CeO₂), graphene oxide (GO), and silver vanadate (AgVO₃) were developed. Synchrotron X-ray diffraction (XRD) confirmed the successful integration of nanofillers, with AgVO₃ notably reducing crystallinity and crystallite size. Fourier-transform infrared (FTIR) spectroscopy and Raman analyses demonstrated strong interfacial bonding between the polymer matrix and the nanomaterials, along with partial reduction of GO. Diffuse reflectance spectroscopy (DRS) indicated a reduced optical bandgap of 2.8 eV, suggesting enhanced electronic interactions and bioactivity. Mechanical testing revealed a Young’s modulus of approximately 26 MPa and superior tensile strength compared to neat PCL, indicating improved mechanical robustness. Wettability studies showed increased hydrophilicity with AgVO₃ incorporation, which can enhance cellular adhesion and proliferation. Antibacterial assays recorded significant inhibition zones against Escherichia coli and Staphylococcus aureus, attributed to sustained Ag⁺ ion release from the scaffold surface. In vivo wound healing experiments using a Sprague–Dawley rat model confirmed accelerated tissue regeneration, achieving approximately 95% wound closure within 14 days, surpassing untreated controls. Collectively, these findings position CeO₂-AgVO₃/GO@PCL scaffolds as highly promising candidates for next-generation wound dressings, offering a synergistic combination of mechanical reinforcement, antibacterial efficacy, and rapid tissue regeneration.</p> Graphical Abstract <p></p>

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Electrospun CeO2-AgVO3/GO@PCL Composite Scaffolds: Structural, Mechanical, and Biological Characterizations for Advanced Biomedical Applications

  • 期刊论文

  • 发表日期：

    2025年5月29日

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  • Hagar M. Mahdy,
  • Hanan Hendawy,
  • Yehia M. Abbas,
  • El-shazly M. Duraia

摘要

Multifunctional electrospun scaffolds are pivotal in advancing tissue engineering and wound healing applications. In this study, electrospun polycaprolactone (PCL) nanocomposite scaffolds incorporating cerium oxide (CeO₂), graphene oxide (GO), and silver vanadate (AgVO₃) were developed. Synchrotron X-ray diffraction (XRD) confirmed the successful integration of nanofillers, with AgVO₃ notably reducing crystallinity and crystallite size. Fourier-transform infrared (FTIR) spectroscopy and Raman analyses demonstrated strong interfacial bonding between the polymer matrix and the nanomaterials, along with partial reduction of GO. Diffuse reflectance spectroscopy (DRS) indicated a reduced optical bandgap of 2.8 eV, suggesting enhanced electronic interactions and bioactivity. Mechanical testing revealed a Young’s modulus of approximately 26 MPa and superior tensile strength compared to neat PCL, indicating improved mechanical robustness. Wettability studies showed increased hydrophilicity with AgVO₃ incorporation, which can enhance cellular adhesion and proliferation. Antibacterial assays recorded significant inhibition zones against Escherichia coli and Staphylococcus aureus, attributed to sustained Ag⁺ ion release from the scaffold surface. In vivo wound healing experiments using a Sprague–Dawley rat model confirmed accelerated tissue regeneration, achieving approximately 95% wound closure within 14 days, surpassing untreated controls. Collectively, these findings position CeO₂-AgVO₃/GO@PCL scaffolds as highly promising candidates for next-generation wound dressings, offering a synergistic combination of mechanical reinforcement, antibacterial efficacy, and rapid tissue regeneration.

Graphical Abstract