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<p>A bismuth oxide-barium oxide (BiO-BaO) nanocomposite was created and characterized using XRD, FT-IR, FE-SEM, TEM, EDX, and UV-DRS techniques. The material had a well-defined crystalline structure, strong metal–oxygen bonding, a uniform nanoscale morphology (30–50&#xa0;nm), and a lower bandgap of 2.65&#xa0;eV, indicating increased photocatalytic activity. BiO-BaO showed much better biological performance than pure Bi₂O₃. It demonstrated increased antimicrobial efficacy against a variety of bacterial and fungal species (<i>Salmonella typhi, Escherichia coli, Proteus vulgaris, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger, Fusarium solani, Curvularia lunata, Rhizoctonia bataticola, and Candida albicans</i>), with greater zones of inhibition. Antioxidant tests showed 88.7% radical scavenging activity at 40&#xa0;µg/mL, higher than pure Bi₂O₃ but lower than Vitamin C. In the HRBC membrane stabilization test, anti-inflammatory activity reached 86.5%, which was comparable to the reference medication. Cytotoxicity studies against MCF-7, KB, and HepG2 cancer cell lines revealed selective activity (IC₅₀ values between 43–56&#xa0;µg/mL), with low toxicity to normal NHDF B cells. The increased bioactivity is related to BaO's ability to facilitate reactive oxygen species (ROS) production and structural stability. These findings indicate that BiO-BaO is a potentially useful multifunctional nanomaterial for biomedical applications such as antibacterial coatings, drug transport, and cancer therapy.</p>

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Synthesis, Optical properties, Engineered BiO-BaO Nanocomposite: a High-Performance Material for Antimicrobial, Antioxidant, and Biomedical Applications

  • 期刊论文

  • 发表日期：

    2025年5月30日

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  • Raja Kaliyaperumal,
  • Karuppiah Nagaraj,
  • Mumtaj Shah,
  • Kamel Hessini,
  • Thavan Kasilingam,
  • Tharini Kumaravel,
  • Ramachandran Gokulan,
  • Lithesh Meenakshisundaram Balasubramaniam ,
  • Ukthi Nakshatra,
  • Stenil Sam

摘要

A bismuth oxide-barium oxide (BiO-BaO) nanocomposite was created and characterized using XRD, FT-IR, FE-SEM, TEM, EDX, and UV-DRS techniques. The material had a well-defined crystalline structure, strong metal–oxygen bonding, a uniform nanoscale morphology (30–50 nm), and a lower bandgap of 2.65 eV, indicating increased photocatalytic activity. BiO-BaO showed much better biological performance than pure Bi₂O₃. It demonstrated increased antimicrobial efficacy against a variety of bacterial and fungal species (Salmonella typhi, Escherichia coli, Proteus vulgaris, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger, Fusarium solani, Curvularia lunata, Rhizoctonia bataticola, and Candida albicans), with greater zones of inhibition. Antioxidant tests showed 88.7% radical scavenging activity at 40 µg/mL, higher than pure Bi₂O₃ but lower than Vitamin C. In the HRBC membrane stabilization test, anti-inflammatory activity reached 86.5%, which was comparable to the reference medication. Cytotoxicity studies against MCF-7, KB, and HepG2 cancer cell lines revealed selective activity (IC₅₀ values between 43–56 µg/mL), with low toxicity to normal NHDF B cells. The increased bioactivity is related to BaO's ability to facilitate reactive oxygen species (ROS) production and structural stability. These findings indicate that BiO-BaO is a potentially useful multifunctional nanomaterial for biomedical applications such as antibacterial coatings, drug transport, and cancer therapy.