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<p>Hemostasis, inflammation, proliferation, and remodeling are the four phases of the biological process of wound healing. A significant consequence of ineffective wound healing, diabetic foot ulcers affect 25% of people with diabetes and frequently result in infection, amputation, or death. Wound healing is slowed down by polymicrobial infections, especially those caused by <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>. Antimicrobial photodynamic therapy (PDT) has emerged as a viable alternative therapeutic treatment, using light-activated photosensitizers (PS) to eradicate microorganisms. Chitosan nanoparticles (CNPs) were used in this study to encapsulate curcumin and C-phycocyanin, two naturally occurring PS with broad light absorption capabilities, to improve their stability and solubility. After topical application of the prepared nanoemulsion to the excision wounds of diabetic Wistar rats, PDT was performed using a 5W LED light. Wound contraction, histopathology, and hematological parameters were assessed. In vivo wound closure study findings showed that wounds treated with CNPs encapsulated PS along with PDT contracted significantly (85.15 ± 0.27%) faster than wounds in other groups.</p>

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Diabetic Wound Healing Effects of Photodynamic Therapy Using Chitosan Nanoparticles Encapsulated with Natural Photosensitizers in Wistar Rats

  • 期刊论文

  • 发表日期：

    2025年5月28日

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  • Jansirani D.,
  • Muthulakshmi L.,
  • Gopukumar S. T.,
  • Rajeswari R.

摘要

Hemostasis, inflammation, proliferation, and remodeling are the four phases of the biological process of wound healing. A significant consequence of ineffective wound healing, diabetic foot ulcers affect 25% of people with diabetes and frequently result in infection, amputation, or death. Wound healing is slowed down by polymicrobial infections, especially those caused by Staphylococcus aureus and Pseudomonas aeruginosa. Antimicrobial photodynamic therapy (PDT) has emerged as a viable alternative therapeutic treatment, using light-activated photosensitizers (PS) to eradicate microorganisms. Chitosan nanoparticles (CNPs) were used in this study to encapsulate curcumin and C-phycocyanin, two naturally occurring PS with broad light absorption capabilities, to improve their stability and solubility. After topical application of the prepared nanoemulsion to the excision wounds of diabetic Wistar rats, PDT was performed using a 5W LED light. Wound contraction, histopathology, and hematological parameters were assessed. In vivo wound closure study findings showed that wounds treated with CNPs encapsulated PS along with PDT contracted significantly (85.15 ± 0.27%) faster than wounds in other groups.