Scholarlink

<p>The current investigation was carried out to evaluate the in vitro anti-inflammatory, antioxidant, and anticancer properties of artificially produced NiO-cellulose nanocomposites (NiO-CNCs). In this study, the green polyol process was used for the preparation of NiO-cellulose nanocomposites in which one of the precursors is cow milk. The synthesized materials were analyzed by TEM, XRD, SEM–EDX, zeta potential, and DLS measurement; moreover, the dimensions of the produced NiO-cellulose nanocomposites were measured by X-ray diffraction. Meanwhile, the surface characteristics were detected through a transmission electron microscope. The study revealed that the average size of NiO-cellulose nanocomposites was approximately 22&#xa0;nm. Through in vitro investigations, the human liver (HEP-2) and colon (502,713 HT-29) cancer cell lines were utilized to find anticancer activities. The cytotoxicity assay of the NiO-CNCs sample against both cancer cell lines reported the IC<sub>50</sub> values of 20&#xa0;µg/ml. Additionally, these NiO-CNCs also show non-toxic or less toxic effects on both cancer cell lines. The results support the promising application of NiO-CNCs in the treatment of cancer after further medicinal studies. Further, it has great antioxidant and anti-inflammatory activity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evaluating the In-Vitro Antioxidant, Anti-inflammatory and Anticancer Potentials of NiO-Cellulose Nanocomposites

  • 期刊论文

  • 发表日期：

    2025年5月27日

查看全文
  • Anshu Tamta,
  • Geetanjali Lohiya,
  • Rajesh Kumar,
  • Asha Kandpal,
  • Bhuwan Chandra,
  • Rajendra Joshi,
  • Narain Datt Kandpal

摘要

The current investigation was carried out to evaluate the in vitro anti-inflammatory, antioxidant, and anticancer properties of artificially produced NiO-cellulose nanocomposites (NiO-CNCs). In this study, the green polyol process was used for the preparation of NiO-cellulose nanocomposites in which one of the precursors is cow milk. The synthesized materials were analyzed by TEM, XRD, SEM–EDX, zeta potential, and DLS measurement; moreover, the dimensions of the produced NiO-cellulose nanocomposites were measured by X-ray diffraction. Meanwhile, the surface characteristics were detected through a transmission electron microscope. The study revealed that the average size of NiO-cellulose nanocomposites was approximately 22 nm. Through in vitro investigations, the human liver (HEP-2) and colon (502,713 HT-29) cancer cell lines were utilized to find anticancer activities. The cytotoxicity assay of the NiO-CNCs sample against both cancer cell lines reported the IC50 values of 20 µg/ml. Additionally, these NiO-CNCs also show non-toxic or less toxic effects on both cancer cell lines. The results support the promising application of NiO-CNCs in the treatment of cancer after further medicinal studies. Further, it has great antioxidant and anti-inflammatory activity.