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<p>Silver carbonate nanoparticles (Ag/Ag₂CO₃) have gained significant attention due to their potential biomedical applications. This study focuses on the synthesis, characterization, and biological evaluation of Ag/Ag₂CO₃ nanoparticles, assessing their pharmacokinetics, metabolic effects, wound healing properties, antimicrobial activity, and molecular interactions. The nanoparticles were successfully synthesized and analyzed using SEM, TEM, and FTIR, confirming their unique morphology and chemical composition. Pharmacokinetic analysis demonstrated excellent intestinal absorption, low toxicity, and minimal interaction with drug-metabolizing enzymes, making them safe for therapeutic applications. The results showed that Ag/Ag₂CO₃ nanoparticles exhibited strong antibacterial activity, with inhibition zones reaching 18.6&#xa0;mm against <i>Pseudomonas aeruginosa</i> at 100 µL (5&#xa0;mg/kg) concentration. Hemolysis remained low at 2.38% for 25&#xa0;µg/mL, indicating good biocompatibility, while wound healing reached near-complete closure by Day 12 in mice treated with 50&#xa0;mg/kg, demonstrating enhanced regenerative potential. Molecular docking analysis revealed moderate binding affinity between Ag/Ag₂CO₃ and key metabolic proteins, suggesting a possible mechanism for their biological effects. These findings highlight Ag/Ag₂CO₃ nanoparticles as promising candidates for medical applications, particularly in metabolic disorder management, wound healing, and antimicrobial treatments. Further research is needed to explore their long-term effects and clinical viability.</p>

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Synthesis of Ag/Ag₂CO₃ Nanoplates to Unlock Next-Generation Biocompatible Solutions for Enhanced Wound Healing, Glycemic Control, and Antibacterial Defense

  • 期刊论文

  • 发表日期：

    2025年5月19日

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  • Ali Umar,
  • Misbah Ullah Khan

摘要

Silver carbonate nanoparticles (Ag/Ag₂CO₃) have gained significant attention due to their potential biomedical applications. This study focuses on the synthesis, characterization, and biological evaluation of Ag/Ag₂CO₃ nanoparticles, assessing their pharmacokinetics, metabolic effects, wound healing properties, antimicrobial activity, and molecular interactions. The nanoparticles were successfully synthesized and analyzed using SEM, TEM, and FTIR, confirming their unique morphology and chemical composition. Pharmacokinetic analysis demonstrated excellent intestinal absorption, low toxicity, and minimal interaction with drug-metabolizing enzymes, making them safe for therapeutic applications. The results showed that Ag/Ag₂CO₃ nanoparticles exhibited strong antibacterial activity, with inhibition zones reaching 18.6 mm against Pseudomonas aeruginosa at 100 µL (5 mg/kg) concentration. Hemolysis remained low at 2.38% for 25 µg/mL, indicating good biocompatibility, while wound healing reached near-complete closure by Day 12 in mice treated with 50 mg/kg, demonstrating enhanced regenerative potential. Molecular docking analysis revealed moderate binding affinity between Ag/Ag₂CO₃ and key metabolic proteins, suggesting a possible mechanism for their biological effects. These findings highlight Ag/Ag₂CO₃ nanoparticles as promising candidates for medical applications, particularly in metabolic disorder management, wound healing, and antimicrobial treatments. Further research is needed to explore their long-term effects and clinical viability.