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<p>Effective wound healing requires bioactive materials that promote cell regeneration and tissue repair. This study investigates the potential of propolis-based electrospun nanofiber patches for enhanced wound healing. Propolis, a natural substance produced by honeybees, is widely recognized for its antimicrobial and regenerative properties. Phytochemical screening confirmed the presence of phenols, flavonoids, and other bioactive compounds associated with wound-healing activity. Gas Chromatography-Mass Spectrometry (GC/MS) analysis identified phenolic and flavonoid compounds as the predominant constituents, and their total content was quantified. The antioxidant potential of propolis was evaluated through a free radical scavenging assay, demonstrating strong efficacy, with an IC50 value of 3.64 ± 0.53&#xa0;µg/ml. Additionally, in vitro assays, including MTT for cell viability and scratch wound-healing assays on 3T3 fibroblast cells, confirmed the biocompatibility and regenerative potential of the crude extract. Propolis-based wound-healing patches were fabricated using chitosan and polyvinyl alcohol (PVA), followed by structural, chemical, and morphological characterization using X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and Field Emission Scanning Electron Microscopy (FESEM). The findings highlight the potential of propolis-infused electrospun nanofiber patches as a promising biomaterial for wound-healing applications, integrating natural bioactives with advanced tissue engineering approaches.</p> Graphical Abstract <p></p>

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A Bioactive Approach for Enhanced Wound Healing Using Propolis-Infused Electrospun Nanofiber Patches

  • 期刊论文

  • 发表日期：

    2025年5月21日

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  • Raghavi Venu,
  • Maria Leslie Kannath,
  • Kanmani Rao,
  • Muhil Rajendran,
  • Anusiya Ganesan,
  • Jaiganesh Rengarajan

摘要

Effective wound healing requires bioactive materials that promote cell regeneration and tissue repair. This study investigates the potential of propolis-based electrospun nanofiber patches for enhanced wound healing. Propolis, a natural substance produced by honeybees, is widely recognized for its antimicrobial and regenerative properties. Phytochemical screening confirmed the presence of phenols, flavonoids, and other bioactive compounds associated with wound-healing activity. Gas Chromatography-Mass Spectrometry (GC/MS) analysis identified phenolic and flavonoid compounds as the predominant constituents, and their total content was quantified. The antioxidant potential of propolis was evaluated through a free radical scavenging assay, demonstrating strong efficacy, with an IC50 value of 3.64 ± 0.53 µg/ml. Additionally, in vitro assays, including MTT for cell viability and scratch wound-healing assays on 3T3 fibroblast cells, confirmed the biocompatibility and regenerative potential of the crude extract. Propolis-based wound-healing patches were fabricated using chitosan and polyvinyl alcohol (PVA), followed by structural, chemical, and morphological characterization using X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and Field Emission Scanning Electron Microscopy (FESEM). The findings highlight the potential of propolis-infused electrospun nanofiber patches as a promising biomaterial for wound-healing applications, integrating natural bioactives with advanced tissue engineering approaches.

Graphical Abstract