Scholarlink

<p>This study focuses on the development of nanofibrous matrix comprising of both synthetic and naturally derived hemicellulose-based polymers for effective wound healing. Herein, poly(ε-caprolactone) (PCL) nanofiber matrices incorporated with arabinoxylan (AX) were synthesized. Characterizations and physiochemical properties of the matrices were examined. Furthermore, cell adhesion and proliferation experiments were carried out using NIH3 T3-E1 fibroblast cells to determine the cytocompatibility and bioactivity of the matrices. The results showed fibers with smooth and beadless surface morphology without any fragments. The majority of nanofibers were in the range of 200–300 nm, with PCL and PCL-AX accounting for 31% and 47% of the nanofibers, respectively. FTIR analysis validated the successful incorporation of AX into matrices by detecting the characteristic peaks of both PCL and AX in the PCL-AX group. The tensile stress–strain curves demonstrated that the nanofibers were stretchy, and tensile strength showed that the percentage elongation of the PCL-AX matrix was greater than that of PCL. Additionally, the nanofibrous matrices exhibited significant swelling properties, achieving a maximum of 23% increase within the first 5&#xa0;h of immersion in a liquid medium. The matrix also maintained consistent water retention over the 12-h observation period. Moreover, the PCL-AX nanofiber matrix considerably improved fibroblast cell attachment and induced cell proliferation. Overall, these findings indicate that the prepared nanofibrous matrices not only offer structural support but also provide mechanical and biological support in the presence of AX. Additionally, PCL-AX nanofiber matrices have substantial potential to improve wound healing by inducing the function of the fibroblast cells.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Arabinoxylan-Incorporated Poly(ε-caprolactone) Nanofiber Matrix Promote Fibroblast Cells Adhesion and Proliferation

  • 期刊论文

  • 发表日期：

    2025年4月9日

查看全文
  • Kiran Konain,
  • Sajida Farid,
  • Shazia Hameed,
  • Fozia Rehman,
  • Muhammad Samie,
  • Faiza Sharif,
  • Muhammad Zaman,
  • Syed Rashid Habib,
  • Jeevithan Elango,
  • Saeed Ur Rahman

摘要

This study focuses on the development of nanofibrous matrix comprising of both synthetic and naturally derived hemicellulose-based polymers for effective wound healing. Herein, poly(ε-caprolactone) (PCL) nanofiber matrices incorporated with arabinoxylan (AX) were synthesized. Characterizations and physiochemical properties of the matrices were examined. Furthermore, cell adhesion and proliferation experiments were carried out using NIH3 T3-E1 fibroblast cells to determine the cytocompatibility and bioactivity of the matrices. The results showed fibers with smooth and beadless surface morphology without any fragments. The majority of nanofibers were in the range of 200–300 nm, with PCL and PCL-AX accounting for 31% and 47% of the nanofibers, respectively. FTIR analysis validated the successful incorporation of AX into matrices by detecting the characteristic peaks of both PCL and AX in the PCL-AX group. The tensile stress–strain curves demonstrated that the nanofibers were stretchy, and tensile strength showed that the percentage elongation of the PCL-AX matrix was greater than that of PCL. Additionally, the nanofibrous matrices exhibited significant swelling properties, achieving a maximum of 23% increase within the first 5 h of immersion in a liquid medium. The matrix also maintained consistent water retention over the 12-h observation period. Moreover, the PCL-AX nanofiber matrix considerably improved fibroblast cell attachment and induced cell proliferation. Overall, these findings indicate that the prepared nanofibrous matrices not only offer structural support but also provide mechanical and biological support in the presence of AX. Additionally, PCL-AX nanofiber matrices have substantial potential to improve wound healing by inducing the function of the fibroblast cells.