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<p>Due to the significant advantages of nanoparticles over conventional systems, there is growing interest in using them for drug delivery and pharmaceutical research. This is especially relevant for statins, which are primarily used to lower cholesterol but generally have low bioavailability. This paper investigates the use of a single emulsion solvent evaporation method to create the necessary solid lipid nanoparticles (SWLNPs) of sugarcane wax dispersed with atorvastatin (ATV). ATV is a well-known drug for having a low oral bioavailability, particularly because of first-pass metabolism. Sugarcane wax is a biocompatible, economical as well as resourceful raw material and is utilized in this work to synthesis nanoparticles. X-ray diffraction analysis (XRD) revealed that the synthesized nanoparticles had a mean particle size of around 258 nm and a crystallinity of around 60%. In addition to that Fourier transform infrared (FTIR) method of spectroscopy was also carried out to further investigate and characterize the nanoparticles. In order to understand the effects of ATV together with sugarcane wax lipid nanoparticles, in vivo studies in rats were carried out to investigate and find total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG), and very low-density lipoprotein (VLDL). The ATV loaded sugarcane wax nanoparticles treatment significantly reduced TC, VLDL, TG, and LDL levels compared to free ATV, demonstrating enhanced anti-hyperlipidemic activity. Overall, ATV loaded sugarcane wax lipid nanoparticles showed improved therapeutic efficiency with a reduced dose. Greenness assessment was performed using AGREE tool revealing excellent greenness of the proposed technique.</p>

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Sugarcane Wax-Based Solid Lipid Nanoparticles as an Atorvastatin Carrier: Characterization and In Vivo Evaluation of Antihyperlipidemic Activity in Rats

  • 期刊论文

  • 发表日期：

    2025年4月7日

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  • Ramsha Shamshad,
  • Saeeda Nadir Ali,
  • Somia Gul,
  • Syed Sarim Ahmed,
  • Ali Dad Chandio,
  • Ayesha Aziz,
  • Philippe Daniel,
  • Iftikhar Ahmed Channa

摘要

Due to the significant advantages of nanoparticles over conventional systems, there is growing interest in using them for drug delivery and pharmaceutical research. This is especially relevant for statins, which are primarily used to lower cholesterol but generally have low bioavailability. This paper investigates the use of a single emulsion solvent evaporation method to create the necessary solid lipid nanoparticles (SWLNPs) of sugarcane wax dispersed with atorvastatin (ATV). ATV is a well-known drug for having a low oral bioavailability, particularly because of first-pass metabolism. Sugarcane wax is a biocompatible, economical as well as resourceful raw material and is utilized in this work to synthesis nanoparticles. X-ray diffraction analysis (XRD) revealed that the synthesized nanoparticles had a mean particle size of around 258 nm and a crystallinity of around 60%. In addition to that Fourier transform infrared (FTIR) method of spectroscopy was also carried out to further investigate and characterize the nanoparticles. In order to understand the effects of ATV together with sugarcane wax lipid nanoparticles, in vivo studies in rats were carried out to investigate and find total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG), and very low-density lipoprotein (VLDL). The ATV loaded sugarcane wax nanoparticles treatment significantly reduced TC, VLDL, TG, and LDL levels compared to free ATV, demonstrating enhanced anti-hyperlipidemic activity. Overall, ATV loaded sugarcane wax lipid nanoparticles showed improved therapeutic efficiency with a reduced dose. Greenness assessment was performed using AGREE tool revealing excellent greenness of the proposed technique.