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<p>Tissue regeneration is an emerging area of research focusing on developing materials that promote blood coagulation and tissue repair and possess antibacterial properties. Herein, we report curcumin/metronidazole-infused alginate beads and highlight their peculiar properties for regeneration. FT-IR reveals C-H vibrations in pure alginate, while curcuminoid and cryptomelane functional groups confirm the bonding of metronidazole and curcumin, respectively. A drastic morphological change was observed with porous, shrunk, and graded structures exhibiting mesoporous features in the drug-loaded beads than pure alginate beads. Enhanced biocompatibility of the materials was obtained through fibroblast cells and erythrocytes as well as zebrafish toxicity assays. Alginate beads displayed enhanced antibacterial properties against <i>S. mutans</i>, <i>E. coli</i>, and <i>E. faecalis</i>. Precisely, <i>S. mutans</i> is a prevalent environmental pathogen that was cultured on alginate beads. The curcumin-infused alginate beads revealed exceptional efficacy in inhibiting the adhesion and growth of <i>S. mutans</i>, emphasizing their potential antibacterial characteristics. All the tested materials exhibited optimal hemostatic characteristics. Antibiotics suppress the growth of microorganisms; alternatively, alginate triggers hemostasis and regeneration functionalities. Thus, curcumin-infused bead is a potential material for the treatment of damaged tissues and upregulates effective regeneration by supplementing its natural curcuminoid.</p>

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Structural, Bactericidal, and Hemostatic Properties of Curcumin-Infused Alginate Hydrogel Beads for Regenerative Applications

  • 期刊论文

  • 发表日期：

    2025年3月19日

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  • Harini P,
  • Saheb Ali,
  • Anju Cecil,
  • Ramadurai M,
  • Raghunandhakumar S,
  • Chitra S

摘要

Tissue regeneration is an emerging area of research focusing on developing materials that promote blood coagulation and tissue repair and possess antibacterial properties. Herein, we report curcumin/metronidazole-infused alginate beads and highlight their peculiar properties for regeneration. FT-IR reveals C-H vibrations in pure alginate, while curcuminoid and cryptomelane functional groups confirm the bonding of metronidazole and curcumin, respectively. A drastic morphological change was observed with porous, shrunk, and graded structures exhibiting mesoporous features in the drug-loaded beads than pure alginate beads. Enhanced biocompatibility of the materials was obtained through fibroblast cells and erythrocytes as well as zebrafish toxicity assays. Alginate beads displayed enhanced antibacterial properties against S. mutans, E. coli, and E. faecalis. Precisely, S. mutans is a prevalent environmental pathogen that was cultured on alginate beads. The curcumin-infused alginate beads revealed exceptional efficacy in inhibiting the adhesion and growth of S. mutans, emphasizing their potential antibacterial characteristics. All the tested materials exhibited optimal hemostatic characteristics. Antibiotics suppress the growth of microorganisms; alternatively, alginate triggers hemostasis and regeneration functionalities. Thus, curcumin-infused bead is a potential material for the treatment of damaged tissues and upregulates effective regeneration by supplementing its natural curcuminoid.