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<p>Hair loss profoundly impacts millions worldwide, affecting both physical appearance and psychological well-being. Tissue engineering holds promise in addressing hair loss through the development of bioengineered follicles that integrate seamlessly with native tissue. Nanoparticle-based drug delivery systems, like hybrid nanoparticles with extracellular vesicles, nanoparticles, and finasteride, enhance therapeutic outcomes. Temperature-sensitive biopolymers and stem cell membrane-loaded minoxidil nanoparticles improve solubility, sustained release, and localized delivery for hair growth. Advances in biomaterials, such as bioinks and plant-derived nanoparticles, expand treatment possibilities. This review explores current understanding of hair follicle regeneration, emphasizing the pivotal roles of cells, biomaterials and nanoparticles.</p>

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Tissue Engineering and Nanoparticle-Based Approaches for Hair Follicle Regeneration

  • 期刊论文

  • 发表日期：

    2025年4月3日

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  • Haluk Çelik,
  • Ayça Bal-Öztürk

摘要

Hair loss profoundly impacts millions worldwide, affecting both physical appearance and psychological well-being. Tissue engineering holds promise in addressing hair loss through the development of bioengineered follicles that integrate seamlessly with native tissue. Nanoparticle-based drug delivery systems, like hybrid nanoparticles with extracellular vesicles, nanoparticles, and finasteride, enhance therapeutic outcomes. Temperature-sensitive biopolymers and stem cell membrane-loaded minoxidil nanoparticles improve solubility, sustained release, and localized delivery for hair growth. Advances in biomaterials, such as bioinks and plant-derived nanoparticles, expand treatment possibilities. This review explores current understanding of hair follicle regeneration, emphasizing the pivotal roles of cells, biomaterials and nanoparticles.