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<p>Poor solubility of anticancer agent presents a significant challenge in drug delivery and necessitates innovative carrier systems for enhanced therapeutic efficacy. The present study aims to develop and characterize a hollow spherical mesoporous alumina nanoconstruct (HMeAN) as a novel inorganic carrier for the poorly soluble anticancer drug sorafenib tosylate (SFB). A hydrothermal synthesis protocol is utilized for the synthesis of HMeAN in the presence of the surfactant Poloxamer F127 and engineered to exploit the self-assembly of non-ionic micelles and inorganic ions, forming a hollow spherical structure with mesopores. The synthesized HMeAN demonstrated a high drug loading capacity and exhibited controlled release via controlled diffusion of solvent molecules. Morphological studies confirmed its spherical shape and particle size distribution of 230 ± 25&#xa0;nm for HMeAN and 275 ± 15&#xa0;nm for the drug-loaded formulation (HMeAN@SFB). The X-ray diffraction analysis revealed a crystalline nature of HMeAN with a size of less than 20&#xa0;nm, achieved through the optimized ratio of Poloxamer F127 and alumina precursor. Controlled thermal treatment facilitated the formation of the hollow structure, as verified by advanced microscopy techniques. In vitro release studies indicated controlled drug release over 16&#xa0;h, with 68% of the drug released at pH 6.8. The findings highlight the potential of HMeAN as an effective drug delivery system, combining high payload capacity, morphological stability, etc. which addresses the major challenge of poor solubility of most of the anticancer agents.</p> Graphical Abstract <p></p>

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Hydrothermal Synthesis and Characterization of Hollow Mesospherical Alumina Nanoconstructs for Enhanced Delivery of Sorafenib Tosylate

  • 期刊论文

  • 发表日期：

    2025年3月4日

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  • Nishant B. Chopade,
  • Mahesh P. More,
  • Sagar Pardeshi,
  • Amol Gholap,
  • Jitentra Naik,
  • Raju R. Thenge,
  • Minal T. Harde,
  • Prashant K. Deshmukh

摘要

Poor solubility of anticancer agent presents a significant challenge in drug delivery and necessitates innovative carrier systems for enhanced therapeutic efficacy. The present study aims to develop and characterize a hollow spherical mesoporous alumina nanoconstruct (HMeAN) as a novel inorganic carrier for the poorly soluble anticancer drug sorafenib tosylate (SFB). A hydrothermal synthesis protocol is utilized for the synthesis of HMeAN in the presence of the surfactant Poloxamer F127 and engineered to exploit the self-assembly of non-ionic micelles and inorganic ions, forming a hollow spherical structure with mesopores. The synthesized HMeAN demonstrated a high drug loading capacity and exhibited controlled release via controlled diffusion of solvent molecules. Morphological studies confirmed its spherical shape and particle size distribution of 230 ± 25 nm for HMeAN and 275 ± 15 nm for the drug-loaded formulation (HMeAN@SFB). The X-ray diffraction analysis revealed a crystalline nature of HMeAN with a size of less than 20 nm, achieved through the optimized ratio of Poloxamer F127 and alumina precursor. Controlled thermal treatment facilitated the formation of the hollow structure, as verified by advanced microscopy techniques. In vitro release studies indicated controlled drug release over 16 h, with 68% of the drug released at pH 6.8. The findings highlight the potential of HMeAN as an effective drug delivery system, combining high payload capacity, morphological stability, etc. which addresses the major challenge of poor solubility of most of the anticancer agents.

Graphical Abstract