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<p>Cervical cancer is the third most common malignancy among women worldwide. Sesamol (SES) is a phytochemical presenting promising biological activities. This study aimed to design a hydrogel containing SES-loaded nanoemulsions to enable vaginal administration for cervical cancer treatment. First, SES was incorporated (SONE-SES) into a previously developed sesame oil nanoemulsion (SONE), showing nanometric size, concentration close to theoretical, and encapsulation efficiency of 67.41%. The nanoemulsion improved the SES cytotoxic action against the HeLa cell line (IC<sub>50</sub> of 42.06&#xa0;µg/mL). A similar response was observed for 1–1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity. The hydrogel was designed considering simulated physiological vaginal conditions, and xanthan and ƙ-carrageenan gums blended in a concentration of 3.5%, and 2:1 proportion presented the best coverage, retention, and mucoadhesion in the cow’s vaginal mucosa. The nanocomposite hydrogel (HG SONE-SES) was prepared by thickening the SONE-SES with gums, which showed the maintenance of SONE-SES’s nanometric size and SES concentration. HG SONE-SES presented a 5.48 mm<sup>2</sup>/g spreadability factor, non-Newtonian pseudoplastic flow, and high mucoadhesion. In the ex vivo permeation, part of the SES was retained in the cow’s vaginal mucosa, justifying its topical application. The HET-CAM classified HG SONE-SES as non-irritant, presenting the intended properties for the local treatment of cervical cancer.</p>

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Mucoadhesive Xanthan-Carrageenan Hydrogel: a Nanocomposite Dosage Form with Sesame Components Designed for Local Therapy of Cervical Cancer

  • 期刊论文

  • 发表日期：

    2025年2月3日

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  • Camila Parcianello Saccol,
  • Milena Meinerz,
  • Vinicius Costa Prado,
  • Marcel Henrique Marcondes Sari,
  • Daniela Mathes,
  • Letícia Bueno Macedo,
  • Daniele Rubert Nogueira-Librelotto,
  • Letícia Cruz

摘要

Cervical cancer is the third most common malignancy among women worldwide. Sesamol (SES) is a phytochemical presenting promising biological activities. This study aimed to design a hydrogel containing SES-loaded nanoemulsions to enable vaginal administration for cervical cancer treatment. First, SES was incorporated (SONE-SES) into a previously developed sesame oil nanoemulsion (SONE), showing nanometric size, concentration close to theoretical, and encapsulation efficiency of 67.41%. The nanoemulsion improved the SES cytotoxic action against the HeLa cell line (IC50 of 42.06 µg/mL). A similar response was observed for 1–1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity. The hydrogel was designed considering simulated physiological vaginal conditions, and xanthan and ƙ-carrageenan gums blended in a concentration of 3.5%, and 2:1 proportion presented the best coverage, retention, and mucoadhesion in the cow’s vaginal mucosa. The nanocomposite hydrogel (HG SONE-SES) was prepared by thickening the SONE-SES with gums, which showed the maintenance of SONE-SES’s nanometric size and SES concentration. HG SONE-SES presented a 5.48 mm2/g spreadability factor, non-Newtonian pseudoplastic flow, and high mucoadhesion. In the ex vivo permeation, part of the SES was retained in the cow’s vaginal mucosa, justifying its topical application. The HET-CAM classified HG SONE-SES as non-irritant, presenting the intended properties for the local treatment of cervical cancer.