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<p>The objectives of this study are to improve medication release and penetration through the creation and optimization of a transethosomal gel containing nimesulide for transdermal administration. Transethosomes, a new vesicular system, were developed utilizing the thin film hydration approach in order to overcome these problems. A 2<sup>3</sup> full factorial design was used to optimize important formulation parameters, including the amount of ethanol and the ratio of phospholipid to edge activator. We looked at how particle size, entrapment efficiency (EE), and polydispersity index (PDI) were affected by the use of Span 80 and Tween 80 as edge activators. With an EE of 93.21%, a PDI of 0.121, and a particle size of 150.7&#xa0;nm, the optimized formulation proved the medication’s stable encapsulation. In order to ensure skin compatibility, the pH of the gelling agent used to prepare the transethosomal gel, Carbopol 934, was modified. &#xa0;A regulated release profile with a cumulative release of 73.97% within 8&#xa0;h was observed in in vitro drug release tests. These findings imply that transethosomal gel laden with nimesulide has great promise as a transdermal medication delivery method that offers consistent and regulated therapeutic effects.&#xa0;</p> Graphical Abstract <p></p>

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“Development and Optimization of Nimesulide Loaded Transethosomal Gel”

  • 期刊论文

  • 发表日期：

    2025年2月6日

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  • Sayali Kamble,
  • Ganesh Bangale,
  • Rutuja Deshmukh,
  • Krishna Dawargave,
  • Dipak Shingare,
  • Omkar Suryawanshi,
  • Kranti Kadam

摘要

The objectives of this study are to improve medication release and penetration through the creation and optimization of a transethosomal gel containing nimesulide for transdermal administration. Transethosomes, a new vesicular system, were developed utilizing the thin film hydration approach in order to overcome these problems. A 23 full factorial design was used to optimize important formulation parameters, including the amount of ethanol and the ratio of phospholipid to edge activator. We looked at how particle size, entrapment efficiency (EE), and polydispersity index (PDI) were affected by the use of Span 80 and Tween 80 as edge activators. With an EE of 93.21%, a PDI of 0.121, and a particle size of 150.7 nm, the optimized formulation proved the medication’s stable encapsulation. In order to ensure skin compatibility, the pH of the gelling agent used to prepare the transethosomal gel, Carbopol 934, was modified.  A regulated release profile with a cumulative release of 73.97% within 8 h was observed in in vitro drug release tests. These findings imply that transethosomal gel laden with nimesulide has great promise as a transdermal medication delivery method that offers consistent and regulated therapeutic effects. 

Graphical Abstract