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<p>The present research aims to formulate and optimize Curcumin nanosponges (CUR-NS) for topical application and to achieve the controlled release of Curcumin (CUR). The emulsion solvent diffusion approach was used to fabricate CUR-loaded NS using polymer (ethyl cellulose) and stabilizer (polyvinyl alcohol). A 3<sup>2</sup> factorial design was used to carry out statistical optimization, in which varying CUR: Ethyl cellulose ratios and speed of rotation were used as independent variables. The optimal combination of both components with appropriate response ranges was obtained by numerical optimization. The optimum CUR-NS formulation was developed utilizing a drug-polymer ratio of 1:1.04 w/w and a speed of rotation of 1800 RPM. CUR-NS exhibited particle size 124.3 ± 1.25&#xa0;nm, entrapment efficiency (EE) 87.72% ± 0.38, and at 8&#xa0;h, 90.62% ± 1.04 percent drug release. Solid-state characterization using DSC, SEM, and XRPD studies further demonstrated homogenous drug distribution in the polymer matrix and reduced crystallinity. In-vitro dissolution studies showed that CUR in the form of NS controlled the rate of CUR dissolution for as long as 8&#xa0;h. Controlled release CUR-NS may show prolonged effects and enhance its permeation through the skin by reducing particle size. An accelerated stability study performed at 40&#xa0;°C ± 2&#xa0;°C and 75% ± 5% RH showed no notable changes in physical characteristics, particle size, EE, or in-vitro release of the drug of the optimized formulation after 90&#xa0;days. As a result, CUR-NS improves efficacy and expands its potential applications in skin care cosmeceuticals.</p>

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Formulation and Optimization of Curcumin Nanosponges to Enhance Biopharmaceutical Attributes for Possible Cosmeceutical Applications

  • 期刊论文

  • 发表日期：

    2025年1月28日

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  • Atishkumar S. Mundada,
  • Shilpa R. Borate

摘要

The present research aims to formulate and optimize Curcumin nanosponges (CUR-NS) for topical application and to achieve the controlled release of Curcumin (CUR). The emulsion solvent diffusion approach was used to fabricate CUR-loaded NS using polymer (ethyl cellulose) and stabilizer (polyvinyl alcohol). A 32 factorial design was used to carry out statistical optimization, in which varying CUR: Ethyl cellulose ratios and speed of rotation were used as independent variables. The optimal combination of both components with appropriate response ranges was obtained by numerical optimization. The optimum CUR-NS formulation was developed utilizing a drug-polymer ratio of 1:1.04 w/w and a speed of rotation of 1800 RPM. CUR-NS exhibited particle size 124.3 ± 1.25 nm, entrapment efficiency (EE) 87.72% ± 0.38, and at 8 h, 90.62% ± 1.04 percent drug release. Solid-state characterization using DSC, SEM, and XRPD studies further demonstrated homogenous drug distribution in the polymer matrix and reduced crystallinity. In-vitro dissolution studies showed that CUR in the form of NS controlled the rate of CUR dissolution for as long as 8 h. Controlled release CUR-NS may show prolonged effects and enhance its permeation through the skin by reducing particle size. An accelerated stability study performed at 40 °C ± 2 °C and 75% ± 5% RH showed no notable changes in physical characteristics, particle size, EE, or in-vitro release of the drug of the optimized formulation after 90 days. As a result, CUR-NS improves efficacy and expands its potential applications in skin care cosmeceuticals.