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<p>Biodegradable Mg and its alloys have become a research frontier to replace existing permanent metallic implants for orthopedic applications. However, their limited bioactivity and premature failure arising from rapid degradation limit full-scale clinical applications. In this study, Mg-based scaffolds with varying hole diameters (0.3&#xa0;mm, 0.5&#xa0;mm, and 1&#xa0;mm) have been fabricated using electric discharge micro drilling (EDMD) treatment to investigate in vitro degradation resistance and bioactivity. After 7-day immersion in simulated body fluid (SBF), the Mg scaffold with a 0.5&#xa0;mm hole diameter demonstrated an acceptable in vitro hydrogen evolution rate, stable pH, and superior degradation resistance due to in situ mineralization of dense and uniform apatite. The scaffold significantly preserved the ultimate compressive strength by 94%, showcasing superior load-bearing capacity. The fractography analysis of Mg scaffold revealed delays in crack initiation, resulting in weakening of the basal texture (0001) by promoting secondary prismatic orientation (10 <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\overline{1 }\)</EquationSource> <EquationSource Format="MATHML"><math> <mover> <mn>1</mn> <mo>¯</mo> </mover> </math></EquationSource> </InlineEquation> 0) facilitated by the twinning phenomenon. This study highlights the significance of hole dimensions in designing Mg scaffolds for improved bioactivity, degradation resistance, and mechanical integrity for orthopedic applications.</p>

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Engineering Mg-based Biodegradable Bone Scaffolds for Improved Bioactivity, Degradation Resistance and Mechanical Integrity

  • 期刊论文

  • 发表日期：

    2025年11月19日

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  • Navdeep Singh Grewal,
  • Ahsan Tareen,
  • Kamal Kumar,
  • Neeraj Sharma

摘要

Biodegradable Mg and its alloys have become a research frontier to replace existing permanent metallic implants for orthopedic applications. However, their limited bioactivity and premature failure arising from rapid degradation limit full-scale clinical applications. In this study, Mg-based scaffolds with varying hole diameters (0.3 mm, 0.5 mm, and 1 mm) have been fabricated using electric discharge micro drilling (EDMD) treatment to investigate in vitro degradation resistance and bioactivity. After 7-day immersion in simulated body fluid (SBF), the Mg scaffold with a 0.5 mm hole diameter demonstrated an acceptable in vitro hydrogen evolution rate, stable pH, and superior degradation resistance due to in situ mineralization of dense and uniform apatite. The scaffold significantly preserved the ultimate compressive strength by 94%, showcasing superior load-bearing capacity. The fractography analysis of Mg scaffold revealed delays in crack initiation, resulting in weakening of the basal texture (0001) by promoting secondary prismatic orientation (10 \(\overline{1 }\) 1 ¯ 0) facilitated by the twinning phenomenon. This study highlights the significance of hole dimensions in designing Mg scaffolds for improved bioactivity, degradation resistance, and mechanical integrity for orthopedic applications.