<p>The hot deformation behavior and structural evolution of the Ti-48Al-2Cr-2Nb with duplex and lamellar initial microstructures were investigated by hot compression test at temperature ranging from 1000 to 1150°C and strain rates from 0.001 to 0.1&#xa0;s⁻¹. Both the work hardening and dynamic softening were observed simultaneously during hot deformation of Ti-48Al-2Cr-2Nb with duplex and lamellar microstructures. The peak stress increased with increasing Z parameter for both initial microstructures. Activation energy of deformation (Q) was calculated about 166 and 238 kJ/mol for duplex and lamellar microstructure, respectively. The lowest value of Q appeared at the temperature of 110 °C and strain rate of 0.001s⁻¹ for both duplex and lamellar microstructures. The workability of alloy at strain rate of 0.1s⁻¹ was poor at all temperatures. Bending and kinking the lamellae and partial dynamic recrystallization were the dominant softening mechanisms during hot deformation up to order/disorder transformation temperature (between 1120 and 1130°C). At the upper temperatures, softening occurred by forming shear bands and bending the lamellae. Maximum workability of both duplex and lamellar microstructures appeared at the temperature of 1100°C, where the maximum amount of recrystallized and decomposed γ phase existed.</p>