<p>Mining-induced seismicity caused by the fracture of extra-thick strata at high positions (ETSHP) presents significant challenges in terms of both prevention and control. This study highlights the systematic application of the Reissner–Mindlin thick plate theory to analyze the fracture behavior of the ETSHP and the spatial evolution of delamination in relation to the mining-induced “two zones” (fracture and bending–subsidence zones). Spatial evolution equations for delamination were derived, elucidating the mechanical relationships among the ETSHP geometry, coal–rock spacing, and goaf development. Numerical simulations and field monitoring revealed that reduced coal seam thickness and greater coal–rock spacing increase the extent of delamination and the amount of stored elastic energy, thereby increasing the likelihood of high-energy seismic events. On the basis of the spatial position of the ETSHP, in this study, differentiated, combined prevention and control technologies are proposed: underground deep-hole blasting for the ETSHP within the fractured zone and surface vertical-well hydraulic fracturing for the ETSHP spanning both fractured and bending-subsidence zones. Field applications validated that these integrated measures significantly reduced high-energy events and stress concentrations. These findings provide new theoretical and engineering frameworks for seismic risk mitigation in deep mines containing ETSHP.</p>