<p>The hyporheic zone is an active ecotone between surface water and groundwater where strong biogeochemical reactions occur, and it underpins various ecosystem functions. In the 21st century, the hyporheic zone has become a research hotspot due to its important role in biogeochemical activities; however, no comprehensive and systematic review of the current literature on the hyporheic zone has been conducted. In this study, we conducted scientometric analysis of 2,308 articles related to the hyporheic zone in the Web of Science Core Collection database using CiteSpace. This article summarizes the literature on the hyporheic zone in the 21st century based on scientometric visualization, thoroughly capturing the recent developments in this field. In addition, we identified and quantitatively analyzed the top authors, publications, references, institutions, countries, and relevant disciplines. Based on the results, we clarify the current developments, research hotspots, and frontiers of research on the hyporheic zone. We also predict the future research trends in this field. This review provides a comprehensive knowledge framework that can provide a detailed and broad perspective on the status and future trends of this interdisciplinary field. </p>